恐惧症-强迫性精神神经症的多中心对照试验。氯丙咪嗪及其与氟哌啶醇和地西泮联用的效果

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90061-8

G.B. Cassano, P. Castrogiovanni, M. Mauri, G. Rutigliano, R. Pirro, G. Cerone, N.P. Nielsen, S. Reitano, N. Guidotti, D. Bedarida, F.P. Marchetti, A. Catalano, M.V. Benecchi, G. Amabile, M. Zanasi, L. Pugliese, M.L. Rocco, A. Balestrieri, M. Tansella, L. Burti, F. Pariante

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引用次数: 12

摘要

1.1. 据报道，氯丙咪嗪对治疗恐惧症患者有效。它已被广泛地与抗焦虑化合物(如苯二氮卓类药物)或主要镇静剂(如丁替罗芬类药物)联合使用，但尚未确定这些治疗方法中任何一种的明显优势。我们进行了一项多中心试验，比较氯丙咪嗪单用与氟哌啶醇或地西泮合用对有强迫和/或恐惧症状的患者的治疗特点。共有54名男女住院患者接受了为期60天的试验，并在双盲条件下接受治疗。实验分为氯丙咪嗪组、氯丙咪嗪与地西泮组、氯丙咪嗪与氟哌啶酮组。采用MMPI、Hamilton的RSD、Overall和Gorham的BPRS、Lorr的IMPS来评估两组患者的精神病理状况和临床疗效。为了安全起见，使用了副作用清单。经过统计处理，从不同中心收集的数据似乎表明，在所有三种治疗中，不同类型的反应。这些数据表明，在使用三种治疗方法可能存在差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A multicenter controlled trial in phobic-obsessive psychoneurosis. The effect of chlorimipramine and of its combinations with haloperidol and diazepam

1.
1. Chlorimipramine has been reported to be effective in the treatment of phobic-obsessive patients. It has been widely used in combination with anti-anxiety compounds such as benzodiazepines, or with major tranquillizers, such as butirophenones, but no clear-cut superiority of anyone of these treatments has been yet established.
2.
2. A multicenter trial was performed to compare the therapeutic characteristics of chlorimipramine alone with those displayed in combination with haloperidol or diazepam in patients showing an obsessive and/or phobic sympomatology.
3.
3. A total of 54 inpatients of both sexes were admitted to a 60-day trial and were treated in double-blind conditions. The experiment was carried-out in three groups: chlorimipramine, chlorimipramine and diazepam, and chlorimipramine and haloperidol.
4.
4. The psychopatological picture and the evaluation of clinical efficacy was assessed by a battery of instruments: the MMPI, the RSD of Hamilton, the BPRS of Overall and Gorham and the IMPS of Lorr. For safety a check-list of side-effects has been used.
5.
5. After statistical processing, the data gathered from various centres seem to indicate differentiated types of response in all three treatments. These data suggest a possible differentiation in the use of the three treatments.

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