{"title":"大鼠骨骼肌和心肌“肌纤维蛋白酶”的肥大细胞起源","authors":"Timothy Edmunds, Ronald J.T. Pennington","doi":"10.1016/0005-2744(81)90079-6","DOIUrl":null,"url":null,"abstract":"<div><p>Autolysis of a washed heavy particle fraction from rat gastrocnemius muscle was largely prevented when the animals were injected with Compound <sup>48</sup>/80 to degranulate mast cells. The ‘myofibrillar protease’ activity appears to be due therefore to the proteolytic enzyme from mast cells. Alkaline proteinase activity (casein substrate) in rat heart preparations was also largely depleted by Compound <sup>48</sup>/80. Autolytic activity was similarly affected in the heavy particle fraction but much less so in the homogenate.</p></div>","PeriodicalId":100159,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Enzymology","volume":"661 1","pages":"Pages 28-31"},"PeriodicalIF":0.0000,"publicationDate":"1981-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0005-2744(81)90079-6","citationCount":"17","resultStr":"{\"title\":\"Mast cell origin of ‘myofibrillar protease’ of rat skeletal and heart muscle\",\"authors\":\"Timothy Edmunds, Ronald J.T. Pennington\",\"doi\":\"10.1016/0005-2744(81)90079-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Autolysis of a washed heavy particle fraction from rat gastrocnemius muscle was largely prevented when the animals were injected with Compound <sup>48</sup>/80 to degranulate mast cells. The ‘myofibrillar protease’ activity appears to be due therefore to the proteolytic enzyme from mast cells. Alkaline proteinase activity (casein substrate) in rat heart preparations was also largely depleted by Compound <sup>48</sup>/80. Autolytic activity was similarly affected in the heavy particle fraction but much less so in the homogenate.</p></div>\",\"PeriodicalId\":100159,\"journal\":{\"name\":\"Biochimica et Biophysica Acta (BBA) - Enzymology\",\"volume\":\"661 1\",\"pages\":\"Pages 28-31\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0005-2744(81)90079-6\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et Biophysica Acta (BBA) - Enzymology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0005274481900796\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Enzymology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0005274481900796","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Mast cell origin of ‘myofibrillar protease’ of rat skeletal and heart muscle
Autolysis of a washed heavy particle fraction from rat gastrocnemius muscle was largely prevented when the animals were injected with Compound 48/80 to degranulate mast cells. The ‘myofibrillar protease’ activity appears to be due therefore to the proteolytic enzyme from mast cells. Alkaline proteinase activity (casein substrate) in rat heart preparations was also largely depleted by Compound 48/80. Autolytic activity was similarly affected in the heavy particle fraction but much less so in the homogenate.
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