大鼠后脑n -乙酰5 -羟色胺(NAS)的免疫组织学定位

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90049-7

Olga M. Pulido , Gregory M. Brown , Lee J. Grota

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引用次数: 6

摘要

1.1. 采用一种特异性抗NAS抗体和荧光素标记的第二抗体，研究了免疫反应性NAS (INAS)在大鼠后脑的地形分布。在小脑颗粒层、第五脑神经脊髓束和脑桥网状结构中证实了INAS的阳性鉴定。在浦肯野细胞的神经元胞体和突起、所有小脑核、蓝斑座和其他脑干区域也发现了INAS。发现INAS的分布模式与血清素和褪黑素不同。在小脑和蓝斑等区域发现了含有INAS和NE的结构重叠，这表明这些物质在某些区域之间可能存在功能联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Localization of N-acetylserotonin (NAS) in the rat hindbrain by immunohistology

1.
1. A specific anti-NAS antibody and fluorescein-labelled second antibody were employed to investigate the topographic distribution of immunoreactive NAS (INAS) in the hindbrain of the rat.
2.
2. Positive identification of INAS was confirmed in the granular layer of the cerebellum, the spinal tract of the fifth cranial nerve and the pontine reticular formation.
3.
3. INAS was also identified in neuronal cell bodies and processes of Purkinje cells, all cerebellar nuclei, the locus coeruleus and other brain stem regions.
4.
4. The pattern of INAS distribution was found to be different from that of serotonin and melatonin.
5.
5. Overlap of INAS- and NE- containing structures was identified in areas such as cerebellum and locus coeruleus, suggesting the possibility of a functional connection between these substances in some regions.

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