F Walter, H D Czarnetzki, H Albert, C Schwokowski, P Junghans, K Jung
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引用次数: 0
摘要
在大鼠胃切除术后6 ~ 12周用15n -甘氨酸进行研究。Graham手术10只，Longmire, g tgemann手术9只。12只大鼠不做手术，作为对照组。在实验开始时，动物们在食物中摄入了单剂量的15n -甘氨酸。在5天内，每12小时测量一次同位素的排泄。所有大鼠均为正氮平衡。Graham手术组大鼠的尿氮排泄量明显低于其他两组大鼠。这些差异可能是由于对氨基酸的吸附速度不同造成的，在这一点上，格雷厄姆操作的大鼠由于没有十二指肠通道而吸收迟缓明显。这些氨基酸吸收的干扰没有加重，因为动物的氮平衡和蛋白质合成速率是正常的。
[Amino acid resorption and protein metabolism following total gastrectomy in the rat].
The investigations were carried out in rats by means of the amino acid 15N-glycinee 6 to 12 weeks after the gastrectomy. 10 rats were operated by Graham and 9 by Longmire, Gütgemann. 12 rats as a control group were not operated. The animals got a single dose 15N-glycin with the food in the beginning of the experiment. The excretion of the isotope was measured every twelve hours for 5 days. All rats had a positive nitrogen balance. The rats operated by Graham excreted with the urine significantly less 15N than the rats of the other two groups. These differences were caused by different fast adsorption of the amino acids likely, at this the rats operated by Graham absorbed retardingly evident qualified by the absent duodenal passage. These disturbances of the amino acid absorption are not aggravating, because the nitrogen balance and the protein synthesis rate of the animals were normal.
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