锂治疗和停药后脑gabaergic和多巴胺能系统

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90040-0

Pardeep Ahluwalia, Darshan S. Grewaal, Radhey L. Singhal

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引用次数: 27

摘要

1.1. 在短期给药和随后的停药后，在几个脑区域检测了多巴胺能和gaba能系统的变化。在大多数检查的区域，锂管理似乎导致多巴胺周转量减少。此外，中脑GABA的周转可能增加，而其他区域的GABA流出量减少。锂戒断导致纹状体多巴胺周转增加，同时其他脑区多巴胺含量进一步下降。除纹状体外，gaba能参数均向控制方向恢复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Brain gabaergic and dopaminergic systems following lithium treatment and withdrawal

1.
1. Changes in dopaminergic and GABAergic systems were examined in several brain regions following short-term lithium administration and subsequent withdrawal.
2.
2. Lithium administration appears to cause a reduction in turnover of dopamine in most regions examined. In addition, there may be increased turnover of GABA in the midbrain, with decreased GABA outflow in other regions.
3.
3. Lithium withdrawal resulted in enhanced striatal dopamine turnover, together with a further decrease in dopamine content in other brain regions. With the exception of striatum, GABAergic parameters returned towards control.

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