每日单剂量抗抑郁药的临床疗效评价

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90102-8

Domenico De Maio, Mariano Sesso, Alessandro Levi Minzi, Massimo A Caponeri, Carmen Mellado, Michele Bonicalzi

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引用次数: 3

摘要

1.1. 针对给药计划与依从性的关系，从治疗等效性和药代动力学等效性两方面综述了分次给药方案与每日一次给药方案的比较数据。研究了神经性抑郁症患者分次(双药)和单次(上午)剂量(100-200 mg/d)的诺非芬。临床结果表明，两种方案在抗抑郁疗效和安全性上没有明显差异。诺非芬的结果与阿米替林(50 - 150mg)的结果进行了比较，阿米替林以三种不同的方案(每日三次剂量，早晨单剂量，晚上单剂量)给予。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Evaluation of the clinical efficacy of single daily doses of antidepressants

1.
1. In the light of the relationship between administration schedule and compliance, comparison data between divided dose regimen and one-time daily dosage of antidepressant drugs are reviewed in terms of therapeutic and pharmacokinetic equivalence.
2.
2. Divided (b.i.d.) and single (morning) doses of nomifensine (100–200 mg/die) were studied in patients affected with neurotic depression. Clinical results show that the two regimens do not differentiate as for antidepressant eff $i$ cacy and safety.
3.
3. Nomifensine findings are compared to those obtained with amitriptyline (50–150 mg) given in three different schedules (three daily doses, single dose at morning, single dose at night).

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