不同精神药物治疗前后精神病人脑脊液γ -氨基丁酸水平的初步研究

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90103-X

Reinhilde Zimmer , Albert W Teelken , Klaus D Meier , Manfred Ackenheil , Karl J Zander

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引用次数: 26

摘要

1.1. 测定不同组精神病患者脑脊液GABA水平。采用两种不同的方法测定脑脊液GABA浓度:a)气相色谱-质谱法和b)荧光检测氨基酸分析法。对照组和未治疗的精神分裂症患者脑脊液GABA水平无差异。4.4。长期住院的精神分裂症患者在服用舒必利30天后和长期服用不同的抗精神病药物期间，脑脊液GABA水平均有升高。在短期住院的精神分裂症患者中，不同的抗精神病药联合苯二氮卓类药物和抗帕金森药物治疗约6周后，观察到脑脊液GABA水平较对照组降低。我们认为脑脊液中GABA的升高可能是使用抗精神病药物的指示。同时服用苯二氮卓类药物和抗帕金森药物可能是脑脊液GABA水平下降的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Preliminary studies on CSF gamma-aminobutyric acid levels in psychiatric patients before and during treatment with different psychotropic drugs

1.
1. Measurements of CSF GABA levels were performed on different groups of psychiatric patients.
2.
2. Two different methods were used for determination of CSF GABA concentration: a) gaschromatography/ mass spectrometry and b) amino acid analysis with fluorescence detection.
3.
3. No difference in CSF GABA levels between control patients and untreated schizophrenic patients was seen.
4.
4. An increase of CSF GABA levels was found after 30 days of treatment with sulpiride and during chronic treatment with different neuroleptics for many years in long-stay hospitalized schizophrenic patients.
5.
5. In short-stay hospitalized schizophrenic patients after a period of about 6 weeks of treatment with different neuroleptics in combination with benzodiazepines and antiparkinsonian drugs a decrease of CSF GABA levels compared with control patients was observed.
6.
6. It is assumed that the increase of GABA in CSF could be indicative for a neuroleptic drug. The simultaneous administration of benzodiazepines and antiparkinsonian drugs might be responsible for the decrease in CSF GABA levels.

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