不同精神药物治疗前后精神病人脑脊液γ -氨基丁酸水平的初步研究

Reinhilde Zimmer , Albert W Teelken , Klaus D Meier , Manfred Ackenheil , Karl J Zander
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引用次数: 26

摘要

1.1. 测定不同组精神病患者脑脊液GABA水平。采用两种不同的方法测定脑脊液GABA浓度:a)气相色谱-质谱法和b)荧光检测氨基酸分析法。对照组和未治疗的精神分裂症患者脑脊液GABA水平无差异。4.4。长期住院的精神分裂症患者在服用舒必利30天后和长期服用不同的抗精神病药物期间,脑脊液GABA水平均有升高。在短期住院的精神分裂症患者中,不同的抗精神病药联合苯二氮卓类药物和抗帕金森药物治疗约6周后,观察到脑脊液GABA水平较对照组降低。我们认为脑脊液中GABA的升高可能是使用抗精神病药物的指示。同时服用苯二氮卓类药物和抗帕金森药物可能是脑脊液GABA水平下降的原因。
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Preliminary studies on CSF gamma-aminobutyric acid levels in psychiatric patients before and during treatment with different psychotropic drugs

  • 1.

    1. Measurements of CSF GABA levels were performed on different groups of psychiatric patients.

  • 2.

    2. Two different methods were used for determination of CSF GABA concentration: a) gaschromatography/ mass spectrometry and b) amino acid analysis with fluorescence detection.

  • 3.

    3. No difference in CSF GABA levels between control patients and untreated schizophrenic patients was seen.

  • 4.

    4. An increase of CSF GABA levels was found after 30 days of treatment with sulpiride and during chronic treatment with different neuroleptics for many years in long-stay hospitalized schizophrenic patients.

  • 5.

    5. In short-stay hospitalized schizophrenic patients after a period of about 6 weeks of treatment with different neuroleptics in combination with benzodiazepines and antiparkinsonian drugs a decrease of CSF GABA levels compared with control patients was observed.

  • 6.

    6. It is assumed that the increase of GABA in CSF could be indicative for a neuroleptic drug. The simultaneous administration of benzodiazepines and antiparkinsonian drugs might be responsible for the decrease in CSF GABA levels.

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