慢性氟哌啶醇治疗不能改变多巴胺能激动剂和胆碱能药物的厌食作用

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90079-5

Martin D. Hynes , Harbans Lal

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引用次数: 0

摘要

1.1. 实验大鼠长期服用氟哌啶醇，并用多巴胺能和胆碱能药物观察其厌食效果。所有的测试药物都显著减少了由于食物缺乏而导致的强迫进食。慢性氟哌啶醇不能改变动物对多巴胺能或胆碱能药物的敏感性。对胆碱能药物外周效应的敏感性有增加的趋势。与目前的数据相反，慢性氟哌啶醇后对多巴胺能药物产生运动刺激和刻板印象的敏感性增加。这些实验表明，慢性抗精神病药后神经递质功能的改变在不同的神经行为系统中有显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Chronic haloperidol treatment fails to alter the anorexic actions of dopaminergic agonists and cholinergic drugs

1.
1. Experimental rats were chronically treated with haloperidol and tested with dopaminergic and cholinergic drugs for their anorexic effects.
2.
2. All of the test drugs significantly reduced the compulsive eating that results from food deprivation.
3.
3. Chronic haloperidol failed to change sensitivity of the animals to dopaminergic or cholinergic drugs. There was a trend towards an increase in sensitivity to a peripheral effect of a cholinergic drug.
4.
4. In contrast to the present data, sensitivity to dopaminergic drugs in producing locomotor stimulation and stereotypy is increased after chronic haloperidol. These experiments suggest that alteration in neurotransmitter functioning after chronic neuroleptics markedly differs in different neurobehavioral systems.

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