附睾醛脱氢酶:药理学特征。

Progress in biochemical pharmacology Pub Date : 1981-01-01

F S Messiha

{"title":"附睾醛脱氢酶:药理学特征。","authors":"F S Messiha","doi":"","DOIUrl":null,"url":null,"abstract":"The in vivo effect of various agents, with different pharmacologic properties, on cytosolic EP-ALDH was studied in the rat. Injection of a large dose of PYZ inhibited EP-ALDH 16 h after the injection. Short-term administration of a moderate daily dosage of PYZ also inhibited endogenous EP-ALDH from saline controls. Semichronic administration of a small daily dosage of DIS resulted in inhibition of EP-ALDH. Short-term administration of drugs with various pharmacologic profile produced little change in the specific activity of EP-ALDH. This is compared with an induction and an inhibition of T-ALDH as a function of treatment with an antiandrogen and an estrogenic drug, respectively. The results show lack of response of EP-ALDH towards pharmacologic intervention which may imply certain specificity for EP-ALDH.","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"167-78"},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Epididymal aldehyde dehydrogenase: a pharmacologic profile.\",\"authors\":\"F S Messiha\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The in vivo effect of various agents, with different pharmacologic properties, on cytosolic EP-ALDH was studied in the rat. Injection of a large dose of PYZ inhibited EP-ALDH 16 h after the injection. Short-term administration of a moderate daily dosage of PYZ also inhibited endogenous EP-ALDH from saline controls. Semichronic administration of a small daily dosage of DIS resulted in inhibition of EP-ALDH. Short-term administration of drugs with various pharmacologic profile produced little change in the specific activity of EP-ALDH. This is compared with an induction and an inhibition of T-ALDH as a function of treatment with an antiandrogen and an estrogenic drug, respectively. The results show lack of response of EP-ALDH towards pharmacologic intervention which may imply certain specificity for EP-ALDH.\",\"PeriodicalId\":76365,\"journal\":{\"name\":\"Progress in biochemical pharmacology\",\"volume\":\"18 \",\"pages\":\"167-78\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in biochemical pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in biochemical pharmacology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

在大鼠体内研究了具有不同药理性质的各种药物对胞浆EP-ALDH的体内影响。大剂量PYZ注射后16 h对EP-ALDH有抑制作用。短期每日中等剂量的PYZ也能抑制生理盐水对照组的内源性EP-ALDH。每日小剂量的半定时给药可抑制EP-ALDH。短期服用不同药理学特征的药物对EP-ALDH的比活性变化不大。这与诱导和抑制T-ALDH分别作为抗雄激素和雌激素药物治疗的功能进行了比较。结果显示EP-ALDH对药物干预缺乏反应，这可能暗示EP-ALDH具有一定的特异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Epididymal aldehyde dehydrogenase: a pharmacologic profile.

The in vivo effect of various agents, with different pharmacologic properties, on cytosolic EP-ALDH was studied in the rat. Injection of a large dose of PYZ inhibited EP-ALDH 16 h after the injection. Short-term administration of a moderate daily dosage of PYZ also inhibited endogenous EP-ALDH from saline controls. Semichronic administration of a small daily dosage of DIS resulted in inhibition of EP-ALDH. Short-term administration of drugs with various pharmacologic profile produced little change in the specific activity of EP-ALDH. This is compared with an induction and an inhibition of T-ALDH as a function of treatment with an antiandrogen and an estrogenic drug, respectively. The results show lack of response of EP-ALDH towards pharmacologic intervention which may imply certain specificity for EP-ALDH.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Progress in biochemical pharmacology

自引率

0.00%

发文量

期刊最新文献

Dietary fiber research. Synthesis of biologically active ether lipids. PAF inhibitors of microbial origin. Studies on diketopiperazine derivatives. Confounding factors in the study of membrane pump abnormalities in essential hypertension and pregnancy-induced hypertension. PAF receptors.