{"title":"细胞松弛素B和秋水仙碱对吉田肉瘤细胞运动和生长的影响。","authors":"S Hosaka, M S Suzuki, H Sato","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effects of cytochalasin B (CB) and colchicine on the motility and growth of cultured Yoshida sarcoma cells are studied by cinematographic methods. CB was found to reduce the average locomotory rate of motile Yoshida sarcoma cells and to enhance the frequency of non-motile cells. On the other hand, colchicine enhanced only the frequency of non-motile cells and did not affect the locomotory rate of motile cells. CB inhibited the growth of Yoshida sarcoma cells at the concentration range of 0.6 to 5 microgram/ml.</p>","PeriodicalId":76727,"journal":{"name":"The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku","volume":"27 1-4","pages":"27-31"},"PeriodicalIF":0.0000,"publicationDate":"1980-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of cytochalasin B and colchicine on the motility and growth of Yoshida sarcoma cells in vitro.\",\"authors\":\"S Hosaka, M S Suzuki, H Sato\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The effects of cytochalasin B (CB) and colchicine on the motility and growth of cultured Yoshida sarcoma cells are studied by cinematographic methods. CB was found to reduce the average locomotory rate of motile Yoshida sarcoma cells and to enhance the frequency of non-motile cells. On the other hand, colchicine enhanced only the frequency of non-motile cells and did not affect the locomotory rate of motile cells. CB inhibited the growth of Yoshida sarcoma cells at the concentration range of 0.6 to 5 microgram/ml.</p>\",\"PeriodicalId\":76727,\"journal\":{\"name\":\"The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku\",\"volume\":\"27 1-4\",\"pages\":\"27-31\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1980-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
采用电影摄影法研究了细胞松弛素B (CB)和秋水仙碱对培养的吉田肉瘤细胞运动和生长的影响。研究发现，白芍能降低吉田肉瘤细胞的平均运动率，提高非运动细胞的频率。另一方面，秋水仙碱只增加非运动细胞的频率，而不影响运动细胞的运动速率。在0.6 ~ 5 μ g /ml浓度范围内，对吉田肉瘤细胞生长有抑制作用。
Effects of cytochalasin B and colchicine on the motility and growth of Yoshida sarcoma cells in vitro.
The effects of cytochalasin B (CB) and colchicine on the motility and growth of cultured Yoshida sarcoma cells are studied by cinematographic methods. CB was found to reduce the average locomotory rate of motile Yoshida sarcoma cells and to enhance the frequency of non-motile cells. On the other hand, colchicine enhanced only the frequency of non-motile cells and did not affect the locomotory rate of motile cells. CB inhibited the growth of Yoshida sarcoma cells at the concentration range of 0.6 to 5 microgram/ml.
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