急性和慢性给药β-苯乙胺对大鼠食物摄入和体重的影响

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90093-X

Colin T. Dourish, Alan A. Boulton

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引用次数: 34

摘要

1.1. 观察雄性Sprague-Dawley大鼠单次注射β-苯乙胺(PEA)后的摄食、饮水及利尿情况，并在给药4周后每隔7天监测一次。单次注射后，PEA减少了24小时的食物摄入量(最大效果为50mg /kg时减少20%)，在四周的治疗期间，耐受性没有达到这种效果。同样，在此期间，PEA引起了体重增加的剂量依赖性减少。PEA的厌食作用似乎是行为上特定于喂养的，因为它没有同时抑制水的摄入或利尿。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The effects of acute and chronic administration of β-phenylethylamine on food intake and body weight in rats

1.
1. The food and water intake and diuresis of male Sprague-Dawley rats were monitored after a single injection of β-phenylethylamine (PEA), and thereafter, at 7 day intervals during 4 weeks of drug treatment.
2.
2. PEA reduced 24 hour food intake (maximal effect of 20% reduction at 50 mg/kg) after a single injection and tolerance did not develop to this effect during four weeks treatment. Similarly PEA caused a dose dependent reduction in body weight gain during this period.
3.
3. The anorectic effect of PEA appears to be behaviourally specific to feeding since there was no concurrent inhibition of water intake or diuresis.

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