大鼠纹状体微量胺与多巴胺的相互作用

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90050-3

Glen B. Baker, Deborah L. Yasensky

{"title":"大鼠纹状体微量胺与多巴胺的相互作用","authors":"Glen B. Baker, Deborah L. Yasensky","doi":"10.1016/0364-7722(81)90050-3","DOIUrl":null,"url":null,"abstract":"<div><ul><li>1.1. The ability of three ‘trace’ amines, namely 2-phenylethylamine (PEA), <math><mtext>p</mtext></math>-tyramine (<math><mtext>p</mtext></math>-TA) and tryptamine (T) to facilitate the release of radiolabelled dopamine (DA) from prisms of rat striatum was investigated. At concentrations of 1.0 μM and 10 μM, all three amines caused a significant increase in DA release when compared to controls. The order of strength for this effect was <math><mtext>p</mtext></math>-TA > PEA > T</li><li>2.2. The addition of an α-methyl group on T caused a significant increase in its ability to release DA.</li><li>3.3. The introduction of nomifensine, a drug which blocks carrier-mediated transport of DA, into the superfusion medium dramatically reduced the amount of DA released from the prisms by the trace amines.</li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90050-3","citationCount":"15","resultStr":"{\"title\":\"Interactions of trace amines with dopamine in rat striatum\",\"authors\":\"Glen B. Baker, Deborah L. Yasensky\",\"doi\":\"10.1016/0364-7722(81)90050-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><ul><li>1.1. The ability of three ‘trace’ amines, namely 2-phenylethylamine (PEA), <math><mtext>p</mtext></math>-tyramine (<math><mtext>p</mtext></math>-TA) and tryptamine (T) to facilitate the release of radiolabelled dopamine (DA) from prisms of rat striatum was investigated. At concentrations of 1.0 μM and 10 μM, all three amines caused a significant increase in DA release when compared to controls. The order of strength for this effect was <math><mtext>p</mtext></math>-TA > PEA > T</li><li>2.2. The addition of an α-methyl group on T caused a significant increase in its ability to release DA.</li><li>3.3. The introduction of nomifensine, a drug which blocks carrier-mediated transport of DA, into the superfusion medium dramatically reduced the amount of DA released from the prisms by the trace amines.</li></ul></div>\",\"PeriodicalId\":20801,\"journal\":{\"name\":\"Progress in neuro-psychopharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0364-7722(81)90050-3\",\"citationCount\":\"15\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in neuro-psychopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0364772281900503\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772281900503","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 15

摘要

1.1. 研究了三种“微量”胺，即2-苯乙胺(PEA)、对酪胺(p-TA)和色胺(T)促进大鼠纹状体棱镜放射标记多巴胺(DA)释放的能力。在1.0 μM和10 μM浓度下，与对照组相比，三种胺均显著增加DA释放量。这种效应的强度顺序为p-TA >豌豆在T2.2。在T上添加α-甲基使其释放da的能力显著提高。将诺米芬(一种阻断DA载体转运的药物)引入到超融合培养基中，可显著减少微量胺从棱镜中释放的DA量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Interactions of trace amines with dopamine in rat striatum

1.
1. The ability of three ‘trace’ amines, namely 2-phenylethylamine (PEA), $p$ -tyramine ( $p$ -TA) and tryptamine (T) to facilitate the release of radiolabelled dopamine (DA) from prisms of rat striatum was investigated. At concentrations of 1.0 μM and 10 μM, all three amines caused a significant increase in DA release when compared to controls. The order of strength for this effect was $p$ -TA > PEA > T
2.
2. The addition of an α-methyl group on T caused a significant increase in its ability to release DA.
3.
3. The introduction of nomifensine, a drug which blocks carrier-mediated transport of DA, into the superfusion medium dramatically reduced the amount of DA released from the prisms by the trace amines.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助