{"title":"细胞因子和一氧化氮之间的相互作用","authors":"Foo Y. Liew","doi":"10.1016/0960-5428(95)00009-Q","DOIUrl":null,"url":null,"abstract":"<div><p>There is now an impressive range of evidence supporting the important role of cytokines in sleep regulation (see Krueger <em>et al.</em>, 1995; De Simoni <em>et al.</em>, 1995). It has also been reported that inhibition of nitric oxide (NO) synthesis suppresses sleep in rabbits (Kapás <em>et al.</em>, 1994). This is not surprising, since NO is closely involved in neurotransmission (Garthwaite, 1991; Schuman and Madison, 1994) and cytokines are the major inducers of NO synthesis (Hibbs <em>et al.</em>, 1990). Further, it is now clear that NO plays an important role in modulating immune responses, possibly through the differential regulation of cytokine synthesis (Taylor-Robinson <em>et al.</em>, 1994). In this article, I will provide evidence for the interactions between cytokines and nitric oxide, and discuss their implications in the regulation of immune responses. I shall illustrate these mainly with results from my coworkers and I, from our laboratory rather than attempting an exhaustive review of the subject.</p></div>","PeriodicalId":79314,"journal":{"name":"Advances in neuroimmunology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0960-5428(95)00009-Q","citationCount":"52","resultStr":"{\"title\":\"Interactions between cytokines and nitric oxide\",\"authors\":\"Foo Y. Liew\",\"doi\":\"10.1016/0960-5428(95)00009-Q\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>There is now an impressive range of evidence supporting the important role of cytokines in sleep regulation (see Krueger <em>et al.</em>, 1995; De Simoni <em>et al.</em>, 1995). It has also been reported that inhibition of nitric oxide (NO) synthesis suppresses sleep in rabbits (Kapás <em>et al.</em>, 1994). This is not surprising, since NO is closely involved in neurotransmission (Garthwaite, 1991; Schuman and Madison, 1994) and cytokines are the major inducers of NO synthesis (Hibbs <em>et al.</em>, 1990). Further, it is now clear that NO plays an important role in modulating immune responses, possibly through the differential regulation of cytokine synthesis (Taylor-Robinson <em>et al.</em>, 1994). In this article, I will provide evidence for the interactions between cytokines and nitric oxide, and discuss their implications in the regulation of immune responses. I shall illustrate these mainly with results from my coworkers and I, from our laboratory rather than attempting an exhaustive review of the subject.</p></div>\",\"PeriodicalId\":79314,\"journal\":{\"name\":\"Advances in neuroimmunology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0960-5428(95)00009-Q\",\"citationCount\":\"52\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in neuroimmunology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/096054289500009Q\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in neuroimmunology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/096054289500009Q","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 52
摘要
现在有一系列令人印象深刻的证据支持细胞因子在睡眠调节中的重要作用(见Krueger et al., 1995;De Simoni et al., 1995)。也有报道称,抑制一氧化氮(NO)合成会抑制兔子的睡眠(Kapás et al., 1994)。这并不奇怪,因为NO与神经传递密切相关(Garthwaite, 1991;Schuman and Madison, 1994)和细胞因子是NO合成的主要诱导因子(Hibbs et al., 1990)。此外,现在很清楚NO在调节免疫反应中发挥重要作用,可能是通过细胞因子合成的差异调节(Taylor-Robinson et al., 1994)。在这篇文章中,我将提供细胞因子和一氧化氮之间相互作用的证据,并讨论它们在免疫反应调节中的意义。我将主要用我和我的同事在我们实验室的结果来说明这些,而不是试图对这个主题进行详尽的回顾。
There is now an impressive range of evidence supporting the important role of cytokines in sleep regulation (see Krueger et al., 1995; De Simoni et al., 1995). It has also been reported that inhibition of nitric oxide (NO) synthesis suppresses sleep in rabbits (Kapás et al., 1994). This is not surprising, since NO is closely involved in neurotransmission (Garthwaite, 1991; Schuman and Madison, 1994) and cytokines are the major inducers of NO synthesis (Hibbs et al., 1990). Further, it is now clear that NO plays an important role in modulating immune responses, possibly through the differential regulation of cytokine synthesis (Taylor-Robinson et al., 1994). In this article, I will provide evidence for the interactions between cytokines and nitric oxide, and discuss their implications in the regulation of immune responses. I shall illustrate these mainly with results from my coworkers and I, from our laboratory rather than attempting an exhaustive review of the subject.