{"title":"钒化合物的致突变性、致癌性和致畸性","authors":"A. Léonard, G.B. Gerber","doi":"10.1016/0165-1110(94)90013-2","DOIUrl":null,"url":null,"abstract":"<div><p>The mutagenic, carcinogenic and teratogenic effects of vanadium and its compounds are reviewed. It is concluded that vanadium is not clastogenic and only weakly mutagenic; it has marked mitogenic activity affecting the distribution of chromosomes during mitosis and possibly causing aneuploidy. The few positive data on effects of vanadium during development leave it open whether direct effects on the embryo or fetus or physiological disturbances in the mother are responsible. No data exist indicating that vanadium is carcinogenic in animals or man, but since it interferes with mitosis and chromosome distribution, the possibility that vanadium might be carcinogenic under certain conditions cannot be dismissed offhand.</p></div>","PeriodicalId":100940,"journal":{"name":"Mutation Research/Reviews in Genetic Toxicology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1994-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0165-1110(94)90013-2","citationCount":"104","resultStr":"{\"title\":\"Mutagenicity, carcinogenicity and teratogenicity of vanadium compounds\",\"authors\":\"A. Léonard, G.B. Gerber\",\"doi\":\"10.1016/0165-1110(94)90013-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The mutagenic, carcinogenic and teratogenic effects of vanadium and its compounds are reviewed. It is concluded that vanadium is not clastogenic and only weakly mutagenic; it has marked mitogenic activity affecting the distribution of chromosomes during mitosis and possibly causing aneuploidy. The few positive data on effects of vanadium during development leave it open whether direct effects on the embryo or fetus or physiological disturbances in the mother are responsible. No data exist indicating that vanadium is carcinogenic in animals or man, but since it interferes with mitosis and chromosome distribution, the possibility that vanadium might be carcinogenic under certain conditions cannot be dismissed offhand.</p></div>\",\"PeriodicalId\":100940,\"journal\":{\"name\":\"Mutation Research/Reviews in Genetic Toxicology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0165-1110(94)90013-2\",\"citationCount\":\"104\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mutation Research/Reviews in Genetic Toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0165111094900132\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research/Reviews in Genetic Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0165111094900132","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Mutagenicity, carcinogenicity and teratogenicity of vanadium compounds
The mutagenic, carcinogenic and teratogenic effects of vanadium and its compounds are reviewed. It is concluded that vanadium is not clastogenic and only weakly mutagenic; it has marked mitogenic activity affecting the distribution of chromosomes during mitosis and possibly causing aneuploidy. The few positive data on effects of vanadium during development leave it open whether direct effects on the embryo or fetus or physiological disturbances in the mother are responsible. No data exist indicating that vanadium is carcinogenic in animals or man, but since it interferes with mitosis and chromosome distribution, the possibility that vanadium might be carcinogenic under certain conditions cannot be dismissed offhand.
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