R B Kelly, F Bonzelius, A Cleves, L Clift-O'Grady, E Grote, G Herman
{"title":"突触囊泡的生物发生。","authors":"R B Kelly, F Bonzelius, A Cleves, L Clift-O'Grady, E Grote, G Herman","doi":"10.1242/jcs.1993.supplement_17.12","DOIUrl":null,"url":null,"abstract":"<p><p>The basic endosomal recycling pathway can be modified to generate transcytotic vesicles, storage vesicles and synaptic vesicles. Sorting into synaptic vesicles requires specialized sorting information not present in the transcytotic and storage vesicle proteins. Using mutagenesis we have distinguished the signals for rapid endocytosis and SV targeting in synaptobrevin. Finally, we have evidence that synaptic vesicles can be generated from an endosomal compartment in vitro.</p>","PeriodicalId":77195,"journal":{"name":"Journal of cell science. Supplement","volume":"17 ","pages":"81-3"},"PeriodicalIF":0.0000,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1242/jcs.1993.supplement_17.12","citationCount":"9","resultStr":"{\"title\":\"Biogenesis of synaptic vesicles.\",\"authors\":\"R B Kelly, F Bonzelius, A Cleves, L Clift-O'Grady, E Grote, G Herman\",\"doi\":\"10.1242/jcs.1993.supplement_17.12\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The basic endosomal recycling pathway can be modified to generate transcytotic vesicles, storage vesicles and synaptic vesicles. Sorting into synaptic vesicles requires specialized sorting information not present in the transcytotic and storage vesicle proteins. Using mutagenesis we have distinguished the signals for rapid endocytosis and SV targeting in synaptobrevin. Finally, we have evidence that synaptic vesicles can be generated from an endosomal compartment in vitro.</p>\",\"PeriodicalId\":77195,\"journal\":{\"name\":\"Journal of cell science. Supplement\",\"volume\":\"17 \",\"pages\":\"81-3\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1242/jcs.1993.supplement_17.12\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of cell science. Supplement\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1242/jcs.1993.supplement_17.12\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of cell science. Supplement","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1242/jcs.1993.supplement_17.12","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The basic endosomal recycling pathway can be modified to generate transcytotic vesicles, storage vesicles and synaptic vesicles. Sorting into synaptic vesicles requires specialized sorting information not present in the transcytotic and storage vesicle proteins. Using mutagenesis we have distinguished the signals for rapid endocytosis and SV targeting in synaptobrevin. Finally, we have evidence that synaptic vesicles can be generated from an endosomal compartment in vitro.
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