诱导稳定的DNA复制大肠杆菌耐受未切除的嘧啶二聚体以紫外线依赖的方式

Mutation Research Letters Pub Date : 1995-01-01 DOI:10.1016/0165-7992(95)90062-4

Milena Sedliaková, Viera Slezáriková, Frantisšek Miroslav Piršel

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引用次数: 3

摘要

对uvr+和uvrB5进行损伤诱导DNA复制(iSDR)。由于前者抑制了二聚体的切除(由代谢处理引起)，两者都含有相似数量的未切除二聚体。由于iSDR发生在uvr+细胞中，而不在uvrB5细胞中，因此我们得出结论，uvr系统可以通过重组iSDR耐受未切除的二聚体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Inducible stable DNA replication of Escherichia coli tolerates unexcised pyrimidine dimers in an uvr-dependent manner

Damage-inducible DNA replication (iSDR) was followed in UV-irradiated E. coli uvr⁺ and uvrB5. Owing to the inhibition of dimer excision in the former (caused by the metabolic treatment), both contained similar amounts of unexcised dimers. Since iSDR took place in uvr⁺ but not in uvrB5 cells, it is concluded that the uvr system can tolerate unexcised dimers through the recombinogenic iSDR.

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Mutation Research Letters

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