希腊犬群全血铅浓度和红细胞δ -氨基乙酰丙酸脱水酶(ALAD)活性。

Z S Polizopoulou, V S Kontos, A F Koutinas, A Papasteriades
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引用次数: 0

摘要

对275只不同年龄、性别和品种的狗进行血铅浓度(BLC)和红细胞ALAD活性测定。66只狗生活在希腊的铅矿区(A组),157只生活在城市地区(B组),52只生活在农村地区(C组)。不同地点的平均BLC分别为326、97和68微克/L,差异有统计学意义(P < 0.05)。平均ALAD活性仅在A组和B组之间差异显著(P < 0.05),在A组和c组之间差异显著(P < 0.05), BLC与ALAD活性呈显著负相关。犬红细胞ALAD活性正常范围为807 ~ 992 μ mol/PBG/LRBC/h。33只A组犬和2只B组犬BLC为350微克/L的犬均未出现急性或慢性铅中毒的临床症状。BLC > 350微克/L的A组30只犬未见红细胞嗜碱性点,未见大量有核红细胞。
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Whole blood lead concentration and erythrocyte delta-aminolevulinic acid dehydratase (ALAD) activity in selected canine populations in Greece.

In a total number of 275 dogs of various ages, sex and breed, blood lead concentrations (BLC) and erythrocyte ALAD activity were measured. Sixty-six of the dogs were living in lead mining areas (Group A), 157 in urban areas (Group B) and 52 in rural areas (Group C) of Greece. Mean BLC differed significantly (P < 0.05) between locations and were 326,97 and 68 micrograms/L, respectively. Mean ALAD activity was significantly different (P < 0.05) only between Groups A and B as between groups A and C. A significant (P < 0.05) negative correlation existed between BLC and ALAD activity. A normal range of erythrocyte ALAD activity of 807-992 mumol/PBG/LRBC/h was established for dogs. None of the 33 Group A dogs and 2 of the Group B dogs that had a BLC of 350 micrograms/L presented clinical signs indicating acute or chronic lead intoxication. No erythrocyte basophilic stippling or large number of nucleated red blood cells were seen in the 30 dogs of Group A with BLC > 350 micrograms/L.

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