{"title":"粗神经孢子虫对唑类药物的耐药性","authors":"Chuck Staben","doi":"10.1006/emyc.1995.1019","DOIUrl":null,"url":null,"abstract":"<div><p>Staben, C. 1995. Resistance to azole drugs in <em>Neurospora crassa. Experimental Mycology</em> 19: 163-165. <em>Neurospora crassa</em> was susceptible to azole drugs: ketoconazole (MIC 1 μg/ml), fluconazole (MIC 5 μg/ml), and SCH39304 (MIC 5 μg/ml). Mutants of <em>N. crassa</em> resistant to ketoconazole were selected and genetically characterized. The seven characterized resistance mutations represented at least four genetic loci. Some mutants, but not all, were also resistant to fluconazole and to SCH39304.</p></div>","PeriodicalId":12110,"journal":{"name":"Experimental Mycology","volume":"19 2","pages":"Pages 163-165"},"PeriodicalIF":0.0000,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/emyc.1995.1019","citationCount":"3","resultStr":"{\"title\":\"Resistance to Azole Drugs in Neurospora crassa\",\"authors\":\"Chuck Staben\",\"doi\":\"10.1006/emyc.1995.1019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Staben, C. 1995. Resistance to azole drugs in <em>Neurospora crassa. Experimental Mycology</em> 19: 163-165. <em>Neurospora crassa</em> was susceptible to azole drugs: ketoconazole (MIC 1 μg/ml), fluconazole (MIC 5 μg/ml), and SCH39304 (MIC 5 μg/ml). Mutants of <em>N. crassa</em> resistant to ketoconazole were selected and genetically characterized. The seven characterized resistance mutations represented at least four genetic loci. Some mutants, but not all, were also resistant to fluconazole and to SCH39304.</p></div>\",\"PeriodicalId\":12110,\"journal\":{\"name\":\"Experimental Mycology\",\"volume\":\"19 2\",\"pages\":\"Pages 163-165\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1006/emyc.1995.1019\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental Mycology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0147597585710195\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental Mycology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0147597585710195","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
摘要
Staben, C. 1995。粗神经孢子虫对唑类药物的耐药性。实验真菌学19:163-165。粗神经孢子虫对唑类药物酮康唑(MIC 1 μg/ml)、氟康唑(MIC 5 μg/ml)、SCH39304 (MIC 5 μg/ml)敏感。选择了对酮康唑具有抗性的突变体，并对其进行了遗传鉴定。7个特征抗性突变代表了至少4个遗传位点。一些突变体，但不是全部，也对氟康唑和SCH39304耐药。
Staben, C. 1995. Resistance to azole drugs in Neurospora crassa. Experimental Mycology 19: 163-165. Neurospora crassa was susceptible to azole drugs: ketoconazole (MIC 1 μg/ml), fluconazole (MIC 5 μg/ml), and SCH39304 (MIC 5 μg/ml). Mutants of N. crassa resistant to ketoconazole were selected and genetically characterized. The seven characterized resistance mutations represented at least four genetic loci. Some mutants, but not all, were also resistant to fluconazole and to SCH39304.
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