垂体腺苷酸环化酶激活肽是人类和猪冠状动脉内皮不依赖的扩张剂。

Agents and actions. Supplements Pub Date : 1995-01-01 DOI:10.1007/978-3-0348-7346-8_38

A Kästner, L Bruch, L Will-Shahab, D Modersohn, G Baumann

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引用次数: 20

摘要

在不同的动物物种中，pacap已被证明是有效的血管舒张剂。人类的数据仍然缺乏。因此，我们研究了pacap38、pacap27和VIP对离体人、猪冠状动脉(HCA和PCA)的影响。我们的数据显示，pacap是内皮独立的血管松弛剂，在HCA中比VIP更有效。n端缩短肽PACAP 6-38和PACAP 6-27也表现出相对有效的血管松弛作用，作为部分激动剂。格列本脲是一种选择性的atp敏感钾通道抑制剂，可以部分逆转pacap的作用，表明这些通道参与了作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pituitary adenylate cyclase activating peptides are endothelium-independent dilators of human and porcine coronary arteries.

The PACAPs have been shown to be potent vasodilators in different animal species. Data in humans are still lacking. Therefore we investigated the effects of PACAP 38, PACAP 27 and VIP on isolated human and porcine coronary arteries (HCA and PCA). Our data show, that the PACAPs are endothelium-independent vasorelaxants, which in HCA are slightly more potent than VIP. The N-terminal shortened peptides PACAP 6-38 and PACAP 6-27 also show relatively potent vasorelaxant effects, acting as partial agonists. Glibenclamide, a selective inhibitor of ATP-sensitive potassium channels, partially reverses the effects of the PACAPs, indicating an involvement of these channels in the mechanism of action.

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Agents and actions. Supplements

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