【不同肾细胞癌细胞原代培养的免疫调节作用】。

Immunitat und Infektion Pub Date : 1995-04-01

B Knöfel, U Junker, K Nuske, A el-Seweifi, K Junker, H Kosmehl, L Jäger

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引用次数: 0

摘要

本研究结果表明，肾细胞癌(RCC)具有部分免疫调节能力(产生IL-6、-10、-11等细胞因子;调节丝裂原诱导的T淋巴细胞转化)。IL-10的产生倾向于与RCC的高分期和分级相关。细胞因子的产生与特定类型的RCC无关。淋巴细胞转化试验(LTT)未检测到T淋巴细胞的直接免疫抑制。

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[Primary culture of different renal cell carcinoma cells with respect to immunomodulatory effects].

The presented results show that renal cell carcinomas (RCC) have partial immunomodulatory capacity (production of cytokines as IL-6, -10, -11; modulation of mitogen-induced transformation of T lymphocytes). The production of IL-10 shows a tendency to correlate with higher staging and grading of RCC. The cytokine production does not correlate with specific types of RCC. Direct immunosuppression of T lymphocytes in lymphocyte transformation tests (LTT) was not detectable.

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Immunitat und Infektion

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