果糖致大鼠高血压、高甘油三酯血症和胞质钙升高:氧化氘预防。

Artery Pub Date : 1994-01-01
S Vasdev, V M Prabhakaran, M Whelan, C A Ford, L Longerich, S Parai
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引用次数: 0

摘要

我们检测了饮用水中5%氧化氘(D20)对果糖致高血压大鼠收缩压、血小板胞质游离钙、主动脉钙摄取和血浆胰岛素、葡萄糖和甘油三酯的影响。选取8周龄雄性Wistar-Kyoto (WKY)大鼠18只,随机分为3组,每组6只。第一组给水;第二组,8%果糖,第三组,8%果糖+ 5% D20作为接下来15周的饮用水。2周后,果糖处理大鼠的收缩压显著高于水处理大鼠(p < 0.01),并在整个研究过程中保持较高水平。15周时,与其他各组相比,果糖处理大鼠收缩压、血小板胞质钙、主动脉钙摄取、血浆葡萄糖、胰岛素和甘油三酯均显著升高(p < 0.01)。与果糖一起给药的氧化氘可防止高血压的发生以及血小板胞质钙、主动脉钙摄取和血浆甘油三酯的相关增加。D20治疗并不能阻止果糖引起的血浆胰岛素和葡萄糖升高。收缩压、胞质游离钙和血管钙摄取的平行增加表明,胞质游离钙的增加与高血压的病理生理有关。D20通过使胞质游离钙正常化来预防高血压。
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Fructose-induced hypertension, hypertriglyceridemia and elevated cytosolic calcium in rats: prevention by deuterium oxide.

We examined the effect of 5% deuterium oxide (D20) in drinking water on systolic blood pressure, platelet cytosolic free calcium, aortic calcium uptake and plasma insulin, glucose and triglycerides in rats with fructose-induced hypertension. Eighteen male Wistar-Kyoto (WKY) rats, age 8 weeks, were divided into 3 groups of 6 animals each. Animals in group I were given water; group II, 8% fructose and group III, 8% fructose + 5% D20 as their drinking water for the next 15 weeks. Systolic blood pressure in the fructose treated rats was significantly higher (p < 0.01) than in animals on water after 2 weeks and remained higher throughout the study. At 15 weeks, systolic blood pressure, platelet cytosolic calcium, aortic calcium uptake and plasma glucose, insulin and triglycerides were significantly higher (p < 0.01) in the fructose treated rats compared with rats from other groups. Deuterium oxide given together with fructose prevented development of high blood pressure and the associated increase in platelet cytosolic calcium, aortic calcium uptake and plasma triglycerides. D20 treatment did not prevent fructose induced increases in plasma insulin and glucose. The parallel increase in systolic blood pressure, cytosolic free calcium, and in vascular calcium uptake suggests that an increased cytosolic free calcium is involved in the pathophysiology of hypertension. D20 prevents this hypertension by normalizing cytosolic free calcium.

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