Maribeth Tillmann, Fred C. Krebs , Renee Wessner , Steven M. Pomeroy , Maureen M. Goodenow , Brian Wigdahl
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引用次数: 10
摘要
逆转录病毒被认为是多种人类疾病的病原体,包括恶性肿瘤、免疫系统功能障碍和神经系统疾病。尽管从患有恶性肿瘤和神经系统疾病的患者身上分离出各种逆转录病毒,但只有人类t细胞淋巴细胞病毒I型(HTLV-I)和人类免疫缺陷病毒(HIV)被明确接受为人类疾病的病原(Hjelle, 1991;Gessain and Gout, 1992;Rosenblatt, 1993)。由于HTLV-I和HIV在疾病进展中的作用越来越明确,因此它们的复制是了解病毒感染导致的致病过程的重要焦点。特别令人感兴趣的是逆转录病毒基因组的表达是由它们的调控单位——长末端重复序列(LTR)——以一种特定于它们感染的细胞目标的方式进行调控的分子机制。