帕金森病运动不足的临床指标:主观与客观评估。

J J van Hilten, J I Hoff, H A Middelkoop, R A Roos
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引用次数: 17

摘要

在这项研究中,我们评估了反映运动活动和不动的不同特征的措施在客观量化运动不足的可行性。由于根据定义,运动不足只能在一段时间内进行评估,因此我们在家中对64名帕金森病患者和104名健康老年人进行了连续5天的活动监测。在患者中,我们还评估了运动不足的监测指标和主观指标与年龄的关系。与健康老年受试者相比,PD患者活动水平降低,不活动时间比例增加,平均不活动时间增加,短时间不活动时间百分比减少。两组之间的差异最突出的是那些纳入或反映不动的措施。此外,在PD患者中,平均不活动时间和短期不活动时间的百分比明显缺乏与年龄和UPDRS获得的临床评分的关系。总之,我们的研究结果强调了运动不足在UPDRS中的代表性不足,以及客观量化PD基本损害的价值。
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The clinimetrics of hypokinesia in Parkinson's disease: subjective versus objective assessment.

In this study we evaluate the feasibility of measures that reflect different characteristics of motor activity and immobility in the objective quantification of hypokinesia. Because by definition hypokinesia can only be assessed over a period of time, continuous activity monitoring was used during 5 successive days in the home setting in 64 patients with Parkinson's disease (PD) and 104 healthy elderly subjects. In the patients we also evaluated the relation between the monitor measures and subjective measures of hypokinesia and age. Compared to the healthy elderly subjects, PD patients have a decreased activity level, increased proportion of time without movement, elevated mean duration of immobility, and decreased percentage of short-lasting immobility periods. Differences between both groups were most prominent for those measures that incorporate or reflect immobility. Moreover, in the PD patients the mean duration of immobility and percentage of short-lasting immobility periods show an apparent lack of relation with age and clinical ratings obtained from the UPDRS. In conclusion, our findings underscore the poor representation of hypokinesia in the UPDRS and value of objective quantification of this fundamental impairment of PD.

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