{"title":"pit1和pit2在生长激素基因调控中的作用。","authors":"V Vila, O Jiménez, A Güell, J L Castrillo","doi":"10.1515/jpem.1993.6.3-4.225","DOIUrl":null,"url":null,"abstract":"<p><p>The role of the POU domain transcription factor Pit-1 (GHF-1) in differentiation and proliferation of the somatotrophic lineage is well known. In our study of differential splicing of the PIT1 gene we found a new protein, Pit-2, in which 26 amino acids are inserted into the transactivation domain. Pit-2 can activate the growth hormone promoter but has lost the ability to activate the prolactin promoter or PIT1 promoter itself.</p>","PeriodicalId":79383,"journal":{"name":"The Journal of pediatric endocrinology","volume":"6 3-4","pages":"225-8"},"PeriodicalIF":0.0000,"publicationDate":"1993-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/jpem.1993.6.3-4.225","citationCount":"8","resultStr":"{\"title\":\"Pit-1 and Pit-2 role in growth hormone gene regulation.\",\"authors\":\"V Vila, O Jiménez, A Güell, J L Castrillo\",\"doi\":\"10.1515/jpem.1993.6.3-4.225\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The role of the POU domain transcription factor Pit-1 (GHF-1) in differentiation and proliferation of the somatotrophic lineage is well known. In our study of differential splicing of the PIT1 gene we found a new protein, Pit-2, in which 26 amino acids are inserted into the transactivation domain. Pit-2 can activate the growth hormone promoter but has lost the ability to activate the prolactin promoter or PIT1 promoter itself.</p>\",\"PeriodicalId\":79383,\"journal\":{\"name\":\"The Journal of pediatric endocrinology\",\"volume\":\"6 3-4\",\"pages\":\"225-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1515/jpem.1993.6.3-4.225\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of pediatric endocrinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1515/jpem.1993.6.3-4.225\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of pediatric endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/jpem.1993.6.3-4.225","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Pit-1 and Pit-2 role in growth hormone gene regulation.
The role of the POU domain transcription factor Pit-1 (GHF-1) in differentiation and proliferation of the somatotrophic lineage is well known. In our study of differential splicing of the PIT1 gene we found a new protein, Pit-2, in which 26 amino acids are inserted into the transactivation domain. Pit-2 can activate the growth hormone promoter but has lost the ability to activate the prolactin promoter or PIT1 promoter itself.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
