D Micic, F Mallo, R Peino, F Cordido, A Leal-Cerro, R V Garcia-Mayor, F F Casanueva
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引用次数: 11
摘要
生长激素(GH)的分泌受一个复杂的中枢和外周信号系统的调节。近年来，人们研究了一种新的释放GH的六肽(his - d - trp - ala - trp - d - ph - lys - nh2)，即GHRP-6。在目前的工作中，GHRP-6的作用机制已经在实验动物模型和肥胖受试者中得到了解决。GHRP-6独立于下丘脑因子GHRH和生长抑素释放生长激素，在肥胖中是一种强大的生长激素释放剂。
Regulation of growth hormone secretion by the growth hormone releasing hexapeptide (GHRP-6).
Growth hormone (GH) secretion is regulated by a complex system of central and peripheral signals. Recently, a new GH-releasing hexapeptide (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) called GHRP-6 which specifically releases GH has been studied. In the present work the mechanism of action of GHRP-6 has been addressed in experimental animal models as well as in obese subjects. GHRP-6 releases GH independently of the hypothalamic factors GHRH and somatostatin and is a powerful GH releaser in obesity.
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