{"title":"超级抗原及其在疾病中的作用。","authors":"B L Kotzin","doi":"10.1080/21548331.1994.11443108","DOIUrl":null,"url":null,"abstract":"<p><p>Because superantigens bind to extremely large numbers of T cells, they are useful for investigating the immune system. Moreover, they appear to have diverse pathologic roles. They may be responsible for massive cytokine release in toxic shock, activate self-reactive T cells in Kawasaki disease and rheumatoid arthritis, and participate in immune tolerance and deficiency.</p>","PeriodicalId":77164,"journal":{"name":"Hospital practice (Office ed.)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1994-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21548331.1994.11443108","citationCount":"19","resultStr":"{\"title\":\"Superantigens and their role in disease.\",\"authors\":\"B L Kotzin\",\"doi\":\"10.1080/21548331.1994.11443108\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Because superantigens bind to extremely large numbers of T cells, they are useful for investigating the immune system. Moreover, they appear to have diverse pathologic roles. They may be responsible for massive cytokine release in toxic shock, activate self-reactive T cells in Kawasaki disease and rheumatoid arthritis, and participate in immune tolerance and deficiency.</p>\",\"PeriodicalId\":77164,\"journal\":{\"name\":\"Hospital practice (Office ed.)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-11-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/21548331.1994.11443108\",\"citationCount\":\"19\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Hospital practice (Office ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/21548331.1994.11443108\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hospital practice (Office ed.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/21548331.1994.11443108","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Because superantigens bind to extremely large numbers of T cells, they are useful for investigating the immune system. Moreover, they appear to have diverse pathologic roles. They may be responsible for massive cytokine release in toxic shock, activate self-reactive T cells in Kawasaki disease and rheumatoid arthritis, and participate in immune tolerance and deficiency.