胃癌患者血清组织蛋白酶B水平、尿组织蛋白酶B排泄及组织蛋白酶B含量的变化。

T Hirano, H Yoshioka
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引用次数: 0

摘要

胃癌患者血清组织蛋白酶B水平及尿组织蛋白酶B排泄量均明显高于对照组。癌组织中组织蛋白酶B的含量明显高于正常组织。胃癌根治性手术后血清组织蛋白酶B水平及尿组织蛋白酶B排泄均恢复到控制值。这些结果提示溶酶体酶、组织蛋白酶B可能在肿瘤生长的发病机制中起作用,也提示这些参数可能是肿瘤恶性程度的指标。
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Serum cathepsin B levels, urinary excretion of cathepsin B and tissue cathepsin B content in the patients with gastric cancer.

Serum cathepsin B levels and urinary excretion of cathepsin B in the patients with gastric cancer were significantly higher than those in the control non-cancer patients. Moreover, cancer tissue cathepsin B content was significantly higher than that in the normal tissue. After radical curative operations for gastric cancers, both serum cathepsin B levels and urinary excretion of cathepsin B were restored to the control values. These results suggest a possible role of lysosomal enzyme, cathepsin B in the pathogenesis of tumor growth, and also suggest that these parameters might be possible indicators for tumor malignancy.

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[Pulmonary hypertension]. [Oral chemotherapeutic agents: the roles in cancer chemotherapy]. Evaluation by microdensitometry and dual energy X-ray absorptiometry of changes in bone metabolism after gastrectomy. Changes in volumetric bone mineral density after gastrectomy as assessed by dual energy X-ray absorptiometry. A case of fibrous histiocytoma of the liver.
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