K Sogawa, T Yamada, J K Kim, M Nishioka, K Matsumoto
{"title":"LEC突变大鼠肝细胞中组蛋白H1超磷酸化与多倍体积累相关。","authors":"K Sogawa, T Yamada, J K Kim, M Nishioka, K Matsumoto","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>In this study, we analyzed effects of copper toxicity on the process of mitosis by examining polyploid accumulation and histone H1 hyper-phosphorylation, which result from defects in mitotic completion, in regenerated LEC rat liver. The proportion of polyploids with 8c nuclear DNA content in LEC rats was significantly higher than that in normal rats (P < 0.05). The degree of histone H1 phosphorylation was about 2.5-fold higher in LEC rat than normal rat. These results suggest that the accumulated copper in LEC mutant rat causes the block of mitotic completion in cell cycle.</p>","PeriodicalId":21140,"journal":{"name":"Research communications in chemical pathology and pharmacology","volume":"84 1","pages":"123-6"},"PeriodicalIF":0.0000,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Polyploid accumulation associated with hyper-phosphorylation of histone H1 in hepatocytes of LEC mutant rat.\",\"authors\":\"K Sogawa, T Yamada, J K Kim, M Nishioka, K Matsumoto\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In this study, we analyzed effects of copper toxicity on the process of mitosis by examining polyploid accumulation and histone H1 hyper-phosphorylation, which result from defects in mitotic completion, in regenerated LEC rat liver. The proportion of polyploids with 8c nuclear DNA content in LEC rats was significantly higher than that in normal rats (P < 0.05). The degree of histone H1 phosphorylation was about 2.5-fold higher in LEC rat than normal rat. These results suggest that the accumulated copper in LEC mutant rat causes the block of mitotic completion in cell cycle.</p>\",\"PeriodicalId\":21140,\"journal\":{\"name\":\"Research communications in chemical pathology and pharmacology\",\"volume\":\"84 1\",\"pages\":\"123-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Research communications in chemical pathology and pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research communications in chemical pathology and pharmacology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Polyploid accumulation associated with hyper-phosphorylation of histone H1 in hepatocytes of LEC mutant rat.
In this study, we analyzed effects of copper toxicity on the process of mitosis by examining polyploid accumulation and histone H1 hyper-phosphorylation, which result from defects in mitotic completion, in regenerated LEC rat liver. The proportion of polyploids with 8c nuclear DNA content in LEC rats was significantly higher than that in normal rats (P < 0.05). The degree of histone H1 phosphorylation was about 2.5-fold higher in LEC rat than normal rat. These results suggest that the accumulated copper in LEC mutant rat causes the block of mitotic completion in cell cycle.
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