{"title":"铅中毒是细胞膜脂肪酸组成改变的反映吗?","authors":"W.E. Donaldson, Scott O. Knowles","doi":"10.1016/0742-8413(93)90003-4","DOIUrl":null,"url":null,"abstract":"<div><p>1. The premise of this review is that many of the biological effects of Pb are reflections of tissue peroxidation.</p><p>2. Enhanced tissue levels of arachidonic acid in Pb toxicosis appear to be involved in the peroxidative changes.</p><p>3. The altered arachidonate metabolism may be related to changes in membrane structure and function.</p><p>4. The induction of enhanced glutathione levels in animal tissues by Pb may afford protection from peroxidative damage.</p></div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"104 3","pages":"Pages 377-379"},"PeriodicalIF":0.0000,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90003-4","citationCount":"98","resultStr":"{\"title\":\"Is lead toxicosis a reflection of altered fatty acid composition of membranes?\",\"authors\":\"W.E. Donaldson, Scott O. Knowles\",\"doi\":\"10.1016/0742-8413(93)90003-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>1. The premise of this review is that many of the biological effects of Pb are reflections of tissue peroxidation.</p><p>2. Enhanced tissue levels of arachidonic acid in Pb toxicosis appear to be involved in the peroxidative changes.</p><p>3. The altered arachidonate metabolism may be related to changes in membrane structure and function.</p><p>4. The induction of enhanced glutathione levels in animal tissues by Pb may afford protection from peroxidative damage.</p></div>\",\"PeriodicalId\":72650,\"journal\":{\"name\":\"Comparative biochemistry and physiology. C: Comparative pharmacology\",\"volume\":\"104 3\",\"pages\":\"Pages 377-379\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0742-8413(93)90003-4\",\"citationCount\":\"98\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comparative biochemistry and physiology. C: Comparative pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0742841393900034\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative biochemistry and physiology. C: Comparative pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0742841393900034","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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