尿道切开术后清洁间歇自导尿治疗复发性尿道狭窄。

T L Tammela, J Permi, M Ruutu, M Talja
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摘要

虽然内镜下光学尿道切开术是尿道狭窄的主要治疗方法,但其复发率高,切开术后疤痕如何停止萎缩是关键问题。在一项对照研究中,分别对25例和24例患者进行了6个月和12个月的内尿道切开术后清洁间歇自我导尿(CIC)治疗复发性尿道狭窄的效果进行了比较。患者很容易学会如何进行CIC:只有一名患者无法在家中进行。所有患者在尿道切开术前后及3、6、9、12个月后进行尿流测定。复发被定义为需要进一步治疗。两组的复发率没有差异,但在6个月时停止置管的患者,12个月时的最大流量明显降低。并发症包括2例无症状性菌尿,10例有症状性尿路感染。CIC是一种非常令人满意的治疗复发性狭窄患者的方法,它易于学习,它可以防止最大流速的下降,因此可以应用于大多数患者,而不是常规的bougage。在本研究的基础上,我们不能确定输尿管切开术后CIC持续时间的最佳时间,也不能确定CIC是否对疾病的自然病程有任何影响。
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Clean intermittent self-catheterization after urethrotomy for recurrent urethral strictures.

Although endoscopic optical urethrotomy is the primary treatment for urethral stricture, it is associated with a high recurrence rate, and the essential problem is how to stop the scar from shrinking after cutting. In a controlled study the effect of treatment of recurrent urethral stricture by internal urethrotomy followed by clean intermittent self-catheterization (CIC) for 6 or 12 months was compared in 25 and 24 patients, respectively. Patients learnt easily how to perform CIC: only one patient was not able to do it at home. All patients were evaluated by uroflowmetry before and immediately after urethrotomy, and 3, 6, 9 and 12 months later. Recurrence was defined as the need for further treatment. There was no difference in the recurrence rate between the two groups, but the maximum flow rate was significantly lower at 12 months in the patients who had ceased catheterization at six months. Complications included in two patients asymptomatic bacteriuria and in 10 patients symptomatic urinary infection. CIC is a very satisfactory method of managing patients with recurrent stricture, it is easy to learn, it prevents a decrease in the maximum flow rate and can thus be applied to most patients instead of regular bouginage. On the basis of the present study we could not determine any optimal time for the duration of CIC after urethrotomy, or whether it has any effect on the natural course of the disease.

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