{"title":"海藻酸盐和钙对固定化Swiss腹腔巨噬细胞分泌IL-1的影响。","authors":"M A Tahri Jouti, H Ramdi, M Lièvremont","doi":"10.3109/10731199309117373","DOIUrl":null,"url":null,"abstract":"<p><p>Murine peritoneal macrophages were immobilized in calcium alginate gel macrobeads, using 1.5% Na-alginate and 50 mM CaCl2. Secretion of IL-1 by immobilized macrophages increased during time and reached 10 fold than IL-1 quantities secreted by adherent macrophages. Calcium and alginate individually enhance production of IL-1 by macrophages and act in synergy when macrophages are immobilized in calcium alginate matrix.</p>","PeriodicalId":77039,"journal":{"name":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","volume":"21 3","pages":"353-8"},"PeriodicalIF":0.0000,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199309117373","citationCount":"1","resultStr":"{\"title\":\"Effect of alginate and calcium on secretion of IL-1 by immobilized Swiss peritoneal macrophages.\",\"authors\":\"M A Tahri Jouti, H Ramdi, M Lièvremont\",\"doi\":\"10.3109/10731199309117373\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Murine peritoneal macrophages were immobilized in calcium alginate gel macrobeads, using 1.5% Na-alginate and 50 mM CaCl2. Secretion of IL-1 by immobilized macrophages increased during time and reached 10 fold than IL-1 quantities secreted by adherent macrophages. Calcium and alginate individually enhance production of IL-1 by macrophages and act in synergy when macrophages are immobilized in calcium alginate matrix.</p>\",\"PeriodicalId\":77039,\"journal\":{\"name\":\"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology\",\"volume\":\"21 3\",\"pages\":\"353-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3109/10731199309117373\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3109/10731199309117373\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/10731199309117373","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
小鼠腹腔巨噬细胞用1.5%海藻酸钠和50 mM CaCl2固定在海藻酸钙凝胶大珠中。固定化巨噬细胞分泌IL-1的量随时间增加，达到贴壁巨噬细胞分泌IL-1的10倍。当巨噬细胞固定在海藻酸钙基质中时，钙和海藻酸盐各自促进巨噬细胞产生IL-1，并协同作用。
Effect of alginate and calcium on secretion of IL-1 by immobilized Swiss peritoneal macrophages.
Murine peritoneal macrophages were immobilized in calcium alginate gel macrobeads, using 1.5% Na-alginate and 50 mM CaCl2. Secretion of IL-1 by immobilized macrophages increased during time and reached 10 fold than IL-1 quantities secreted by adherent macrophages. Calcium and alginate individually enhance production of IL-1 by macrophages and act in synergy when macrophages are immobilized in calcium alginate matrix.
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