{"title":"两性霉素B脂质体治疗指数增高。","authors":"P Legrand, A Vertut-Doï, J Bolard","doi":"10.3109/10731199309117379","DOIUrl":null,"url":null,"abstract":"<p><p>Liposomes represent for amphotericin B (AmB) a promising delivery system that may reduce the important toxicity of the drug. Liposomal AmB has a higher therapeutic index than AmB alone and allows to use larger doses. The mechanism of reduced toxicity may be related to a better targeting ability, a protective effect, and a selective transfer of liposomes. Anyway the liposomes intercalated AmB tends to be uptaken by organs that belong to the reticuloendothelial system, where fungi, the target cells, are localized.</p>","PeriodicalId":77039,"journal":{"name":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","volume":"21 3","pages":"407-13"},"PeriodicalIF":0.0000,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199309117379","citationCount":"4","resultStr":"{\"title\":\"Liposomal amphotericin B bases of therapeutic index increase.\",\"authors\":\"P Legrand, A Vertut-Doï, J Bolard\",\"doi\":\"10.3109/10731199309117379\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Liposomes represent for amphotericin B (AmB) a promising delivery system that may reduce the important toxicity of the drug. Liposomal AmB has a higher therapeutic index than AmB alone and allows to use larger doses. The mechanism of reduced toxicity may be related to a better targeting ability, a protective effect, and a selective transfer of liposomes. Anyway the liposomes intercalated AmB tends to be uptaken by organs that belong to the reticuloendothelial system, where fungi, the target cells, are localized.</p>\",\"PeriodicalId\":77039,\"journal\":{\"name\":\"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology\",\"volume\":\"21 3\",\"pages\":\"407-13\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3109/10731199309117379\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3109/10731199309117379\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/10731199309117379","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Liposomal amphotericin B bases of therapeutic index increase.
Liposomes represent for amphotericin B (AmB) a promising delivery system that may reduce the important toxicity of the drug. Liposomal AmB has a higher therapeutic index than AmB alone and allows to use larger doses. The mechanism of reduced toxicity may be related to a better targeting ability, a protective effect, and a selective transfer of liposomes. Anyway the liposomes intercalated AmB tends to be uptaken by organs that belong to the reticuloendothelial system, where fungi, the target cells, are localized.
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