I Bodis-Wollner, J C Borod, B Cicero, C S Haywood, S Raskin, L Mylin, M Sliwinski, A Falk, M D Yahr
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引用次数: 31
摘要
研究了无痴呆的帕金森病(PD)患者的事件相关电位(ERPs)与认知功能的关系。使用听觉和视觉刺激;30名受试者参加听觉研究,20名受试者参加视觉研究。患者组在性别、年龄、教育程度、病程和认知功能水平方面没有差异。视觉刺激是随机呈现的2.3个cpd正弦光栅模式(倾斜与垂直空间方向)。听觉刺激是在70 dB SPL下以1.1/秒的速率呈现的音调,同样使用古怪范式(1.5K vs. 1K音调)。所有患者都进行了神经心理测试,以测量语言流畅性、记忆力、视觉空间感知和抽象推理。P300和N200异常与许多这些测量相关,例如,较长的ERP潜伏期与认知功能测试中的较低分数有关。结果模式表明,听觉和视觉erp与非痴呆性PD患者的不同神经心理功能亚群相关,N200可能为临床应用提供新的指标。
Modality dependent changes in event-related potentials correlate with specific cognitive functions in nondemented patients with Parkinson's disease.
The relationship between event-related potentials (ERPs) and cognitive functioning was studied in patients with Parkinson's Disease (PD) but without dementia. Auditory and visual stimuli were used; 30 subjects participated in the auditory study and 20 in the visual study. Patient groups did not differ with respect to gender, age, education, illness duration, and level of cognitive functioning. Visual stimuli were 2.3 cpd sinusoidal grating patterns randomly presented in an oddball paradigm (oblique vs. vertical spatial orientation). Auditory stimuli were tones presented at 70 dB SPL at a rate of 1.1/second, also using the oddball paradigm (1.5K vs. 1K tones). All patients were given neuropsychological tests to measure verbal fluency, memory, visual spatial perception, and abstract reasoning. P300 and N200 abnormalities correlated with a number of these measures, such that longer ERP latencies were related to lower scores on tests of cognitive functioning. Patterns of results suggest that auditory and visual ERPs correlate with different subsets of neuropsychological functions in nondemented PD patients and that N200 may provide a new metric for clinical use.