豚鼠丘脑下核神经元放电模式的决定因素:体内和体外比较。

P G Overton, S A Greenfield
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引用次数: 54

摘要

为了确定传入输入在多大程度上决定了丘脑下核(STN)的神经元放电模式,对体内和体外记录的STN神经元进行了比较(主要是去神经的制备)。在体内,大多数细胞表现出不规则的放电模式,尽管一些细胞表现出爆裂放电的证据。相比之下,所有细胞在体外都有规律的放电模式。体内纹状体复合体的电刺激诱导STN神经元的短潜伏期抑制,随后是一阵尖峰。这些效应可以在体外重现;超极化脉冲在终止时产生缓慢的去极化电位,并伴有动作电位的爆发。因此,有证据表明传入事件在决定STN神经元的放电模式中起着重要作用。然而,细胞也具有固有的膜特性,允许输入触发单个尖峰或脉冲。
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Determinants of neuronal firing pattern in the guinea-pig subthalamic nucleus: an in vivo and in vitro comparison.

To ascertain the extent to which neuronal firing pattern in the subthalamic nucleus (STN) is determined by afferent inputs, a comparison was made between STN neurons recorded in vivo and in vitro (a largely denervated preparation). In vivo, the majority of cells exhibited an irregular firing pattern, although some showed evidence of burst firing. In contrast, all cells had a regular firing pattern in vitro. Electrical stimulation of the striatopallidal complex in vivo induced a short latency inhibition in STN neurons, followed by a burst of spikes. These effects could be reproduced in vitro; hyperpolarising pulses gave rist to a slow depolarising potential upon termination, which was accompanied by a burst of action potentials. Hence, the evidence suggests that afferents play an important role in determining the firing pattern of STN neurons. However, the cells also possess intrinsic membrane properties which allow inputs to trigger either single spikes or bursts.

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