抗体结合位点的模型构建。

Therapeutic immunology Pub Date : 1995-04-01

J Bajorath, J Novotny

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引用次数: 0

摘要

布鲁克海文蛋白质数据库中可用的抗体片段的高质量晶体结构的数量正在迅速增加。这些结构提供了大量的知识基础和支持新的抗体结合位点的模型构建。我们回顾了抗体结构的一些基本原理，描述了基于结构的建模过程，并指出了建模方法的优点和缺点。讨论了抗体模型的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Model building of antibody combining sites.

The number of high quality crystal structures of antibody fragments available in the Brookhaven Protein Data Bank is rapidly increasing. These structures provide a substantial knowledge base and support model building of novel antibody combining sites. We review some basic principles of antibody structure, describe structure-based modelling procedures, and indicate the strengths and weaknesses of the modelling approach. Applications of antibody models are discussed.

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Therapeutic immunology

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