B1-Insensitive, Single-Shot Localization and Water Suppression

A technique for single-shot, localized, water-suppressedin vivo¹H NMR with high immunity toB₁inhomogeneities is described. The single-shot localization is based on complete outer-volume suppression which is achieved with optimized, adiabatic BIR-4 pulses in combination withB₀gradient modulation.B₁-insensitive water suppression is achieved with BISTRO, a train of selective adiabatic full-passage pulses interleaved withB₀gradient crushers. Computer simulations based on the Bloch equations, experimental images of the localized volume, andin vivo¹H spectroscopy experiments demonstrate the excellent spatial localization and water suppression.