{"title":"神经系统中的PAF和PAF乙酰水解酶","authors":"Mitsuharu Hattori, Junken Aoki, Hiroyuki Arai, Keizo Inoue","doi":"10.1016/0929-7855(96)00514-7","DOIUrl":null,"url":null,"abstract":"<div><p>PAF acetylhydrolase is a key enzyme of PAF inactivation. Intracellular PAF acetylhydrolase isoform Ib is a heterotrimeric enzyme composed of α-, β- and γ-subunits. The β- and γ-subunits act as a catalytic unit and their amino acid sequences are homologous. The α-subunit is not essential for catalytic activity but is a product of the causative gene for Miller-Dicker lissencephaly, suggesting this subunit plays an important role in brain development.</p></div>","PeriodicalId":79347,"journal":{"name":"Journal of lipid mediators and cell signalling","volume":"14 1","pages":"Pages 99-102"},"PeriodicalIF":0.0000,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0929-7855(96)00514-7","citationCount":"15","resultStr":"{\"title\":\"PAF and PAF acetylhydrolase in the nervous system\",\"authors\":\"Mitsuharu Hattori, Junken Aoki, Hiroyuki Arai, Keizo Inoue\",\"doi\":\"10.1016/0929-7855(96)00514-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>PAF acetylhydrolase is a key enzyme of PAF inactivation. Intracellular PAF acetylhydrolase isoform Ib is a heterotrimeric enzyme composed of α-, β- and γ-subunits. The β- and γ-subunits act as a catalytic unit and their amino acid sequences are homologous. The α-subunit is not essential for catalytic activity but is a product of the causative gene for Miller-Dicker lissencephaly, suggesting this subunit plays an important role in brain development.</p></div>\",\"PeriodicalId\":79347,\"journal\":{\"name\":\"Journal of lipid mediators and cell signalling\",\"volume\":\"14 1\",\"pages\":\"Pages 99-102\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0929-7855(96)00514-7\",\"citationCount\":\"15\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of lipid mediators and cell signalling\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0929785596005147\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of lipid mediators and cell signalling","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0929785596005147","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
PAF acetylhydrolase is a key enzyme of PAF inactivation. Intracellular PAF acetylhydrolase isoform Ib is a heterotrimeric enzyme composed of α-, β- and γ-subunits. The β- and γ-subunits act as a catalytic unit and their amino acid sequences are homologous. The α-subunit is not essential for catalytic activity but is a product of the causative gene for Miller-Dicker lissencephaly, suggesting this subunit plays an important role in brain development.
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