{"title":"血小板活化因子和生长抑素激活丝裂原活化蛋白激酶(MAP激酶)和花生四烯酸酯释放","authors":"Takao Shimizu, Mikiro Mori, Haruhiko Bito, Chie Sakanaka, Sadaharu Tabuchi, Makoto Aihara, Kazuhiko Kume","doi":"10.1016/0929-7855(96)00515-9","DOIUrl":null,"url":null,"abstract":"<div><p>Platelet-activating factor (PAF) receptor and somatostatin receptor (SSTR4) were cloned, and their primary structures were identified. They are both highly expressed in the rat hippocampus. When expressed in Chinese hamster ovary cells, these receptors activated mitogen-activated protein (MAP) kinase cascade and phosphilipase A<sub>2</sub>. Arachidonic acid or its derivatives, thus produced by the activation of these receptors may play some roles in synaptic transmission and synaptic plasticity.</p></div>","PeriodicalId":79347,"journal":{"name":"Journal of lipid mediators and cell signalling","volume":"14 1","pages":"Pages 103-108"},"PeriodicalIF":0.0000,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0929-7855(96)00515-9","citationCount":"15","resultStr":"{\"title\":\"Platelet-activating factor and somatostatin activate mitogen-activated protein kinase (MAP kinase) and arachidonate release\",\"authors\":\"Takao Shimizu, Mikiro Mori, Haruhiko Bito, Chie Sakanaka, Sadaharu Tabuchi, Makoto Aihara, Kazuhiko Kume\",\"doi\":\"10.1016/0929-7855(96)00515-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Platelet-activating factor (PAF) receptor and somatostatin receptor (SSTR4) were cloned, and their primary structures were identified. They are both highly expressed in the rat hippocampus. When expressed in Chinese hamster ovary cells, these receptors activated mitogen-activated protein (MAP) kinase cascade and phosphilipase A<sub>2</sub>. Arachidonic acid or its derivatives, thus produced by the activation of these receptors may play some roles in synaptic transmission and synaptic plasticity.</p></div>\",\"PeriodicalId\":79347,\"journal\":{\"name\":\"Journal of lipid mediators and cell signalling\",\"volume\":\"14 1\",\"pages\":\"Pages 103-108\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0929-7855(96)00515-9\",\"citationCount\":\"15\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of lipid mediators and cell signalling\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0929785596005159\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of lipid mediators and cell signalling","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0929785596005159","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Platelet-activating factor and somatostatin activate mitogen-activated protein kinase (MAP kinase) and arachidonate release
Platelet-activating factor (PAF) receptor and somatostatin receptor (SSTR4) were cloned, and their primary structures were identified. They are both highly expressed in the rat hippocampus. When expressed in Chinese hamster ovary cells, these receptors activated mitogen-activated protein (MAP) kinase cascade and phosphilipase A2. Arachidonic acid or its derivatives, thus produced by the activation of these receptors may play some roles in synaptic transmission and synaptic plasticity.
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