Anna Petroni, Milena Blasevich, Patrizia La Spada, Nadia Papini, Claudio Galli
{"title":"视黄酸分化神经母细胞瘤细胞中花生四烯酸的合成和脂质代谢","authors":"Anna Petroni, Milena Blasevich, Patrizia La Spada, Nadia Papini, Claudio Galli","doi":"10.1016/0929-7855(96)00506-8","DOIUrl":null,"url":null,"abstract":"<div><p>SK-N-BE cells were differentiated (D) to neurons with retinoic acid. Total <em>n</em> - 6 polyunsaturated fatty acids (PUFA), especially arachidonic acid (AA), were increased in D versus ND cells. AA synthesis from linoleic acid (LA) and phospholipid (PL) synthesis from glycerol were initially elevated, whereas both processes were reduced approaching differentiation. At this stage, the incorporation of glycerol in triglycerides was enhanced. Formation of long chain PUFA and synthesis of acceptors (PL) for esterification, during RA-induced SK-N-BE differentiation, appear to be associated.</p></div>","PeriodicalId":79347,"journal":{"name":"Journal of lipid mediators and cell signalling","volume":"14 1","pages":"Pages 39-44"},"PeriodicalIF":0.0000,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0929-7855(96)00506-8","citationCount":"2","resultStr":"{\"title\":\"Arachidonic acid synthesis and lipid metabolism in retinoic acid-differentiated neuroblastoma cells\",\"authors\":\"Anna Petroni, Milena Blasevich, Patrizia La Spada, Nadia Papini, Claudio Galli\",\"doi\":\"10.1016/0929-7855(96)00506-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>SK-N-BE cells were differentiated (D) to neurons with retinoic acid. Total <em>n</em> - 6 polyunsaturated fatty acids (PUFA), especially arachidonic acid (AA), were increased in D versus ND cells. AA synthesis from linoleic acid (LA) and phospholipid (PL) synthesis from glycerol were initially elevated, whereas both processes were reduced approaching differentiation. At this stage, the incorporation of glycerol in triglycerides was enhanced. Formation of long chain PUFA and synthesis of acceptors (PL) for esterification, during RA-induced SK-N-BE differentiation, appear to be associated.</p></div>\",\"PeriodicalId\":79347,\"journal\":{\"name\":\"Journal of lipid mediators and cell signalling\",\"volume\":\"14 1\",\"pages\":\"Pages 39-44\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0929-7855(96)00506-8\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of lipid mediators and cell signalling\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0929785596005068\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of lipid mediators and cell signalling","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0929785596005068","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
摘要
k - n - be细胞在维甲酸作用下分化为神经元(D)。总n - 6多不饱和脂肪酸(PUFA)，特别是花生四烯酸(AA)在D和ND细胞中增加。从亚油酸(LA)合成AA和从甘油合成磷脂(PL)最初升高，但在接近分化时，这两个过程都减少了。在这个阶段，甘油在甘油三酯中的掺入增强。在ra诱导的SK-N-BE分化过程中，长链PUFA的形成和酯化受体(PL)的合成似乎是相关的。
Arachidonic acid synthesis and lipid metabolism in retinoic acid-differentiated neuroblastoma cells
SK-N-BE cells were differentiated (D) to neurons with retinoic acid. Total n - 6 polyunsaturated fatty acids (PUFA), especially arachidonic acid (AA), were increased in D versus ND cells. AA synthesis from linoleic acid (LA) and phospholipid (PL) synthesis from glycerol were initially elevated, whereas both processes were reduced approaching differentiation. At this stage, the incorporation of glycerol in triglycerides was enhanced. Formation of long chain PUFA and synthesis of acceptors (PL) for esterification, during RA-induced SK-N-BE differentiation, appear to be associated.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
