{"title":"基于傅里叶变换的蛋白质分析中氨基酸参数的选择。","authors":"J Lazović","doi":"10.1093/bioinformatics/12.6.553","DOIUrl":null,"url":null,"abstract":"<p><p>Fourier analysis of the parametric profile of a sequence for the detection and localization of the structural motifs that are characteristic for biologically related proteins has been proposed. In order to select parameters that are most appropriate for this analysis, the informational capacity of 226 physicochemical, thermodynamic, structural and statistical amino acid parameters was analyzed. Based on the results, obtained for the four functionally unrelated protein model groups (lysozyme c, HIV-1 gp120, tubulin and tau proteins, and steroid hormone receptors), the electron-ion interaction potential has been selected as the unique amino acid property that can be used in Fourier transform-based analysis of proteins, independently of their biological function.</p>","PeriodicalId":77081,"journal":{"name":"Computer applications in the biosciences : CABIOS","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/bioinformatics/12.6.553","citationCount":"40","resultStr":"{\"title\":\"Selection of amino acid parameters for Fourier transform-based analysis of proteins.\",\"authors\":\"J Lazović\",\"doi\":\"10.1093/bioinformatics/12.6.553\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Fourier analysis of the parametric profile of a sequence for the detection and localization of the structural motifs that are characteristic for biologically related proteins has been proposed. In order to select parameters that are most appropriate for this analysis, the informational capacity of 226 physicochemical, thermodynamic, structural and statistical amino acid parameters was analyzed. Based on the results, obtained for the four functionally unrelated protein model groups (lysozyme c, HIV-1 gp120, tubulin and tau proteins, and steroid hormone receptors), the electron-ion interaction potential has been selected as the unique amino acid property that can be used in Fourier transform-based analysis of proteins, independently of their biological function.</p>\",\"PeriodicalId\":77081,\"journal\":{\"name\":\"Computer applications in the biosciences : CABIOS\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1093/bioinformatics/12.6.553\",\"citationCount\":\"40\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Computer applications in the biosciences : CABIOS\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/bioinformatics/12.6.553\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computer applications in the biosciences : CABIOS","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/bioinformatics/12.6.553","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Selection of amino acid parameters for Fourier transform-based analysis of proteins.
Fourier analysis of the parametric profile of a sequence for the detection and localization of the structural motifs that are characteristic for biologically related proteins has been proposed. In order to select parameters that are most appropriate for this analysis, the informational capacity of 226 physicochemical, thermodynamic, structural and statistical amino acid parameters was analyzed. Based on the results, obtained for the four functionally unrelated protein model groups (lysozyme c, HIV-1 gp120, tubulin and tau proteins, and steroid hormone receptors), the electron-ion interaction potential has been selected as the unique amino acid property that can be used in Fourier transform-based analysis of proteins, independently of their biological function.
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