Periodontal tissue regeneration using fibrin tissue adhesive material in vitro and in vivo.

The purpose of this study was to determine the effects of a fibrin tissue adhesive material (FAM) on periodontal tissue regeneration. In an in vitro study comparing osteogenic cells with gingival fibroblasts, it was shown that the degradation of FAM adjacent to the osteogenic cells was faster than that adjacent to the gingival fibroblasts. In two in vivo studies in dogs where surgical bony defects were created, it was shown through histometric measurements that in the sites where FAM was applied, more new bone was found than in the control sites. It was concluded that FAM may enhance periodontal tissue regeneration.