痴呆的神经化学相关因素

Andrew W. Procter
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引用次数: 18

摘要

阿尔茨海默病的神经化学病理研究表明,在疾病的早期,相对较少的神经递质异常是明显的。最可靠和一致的变化是在皮质和皮质锥体神经元的胆碱能神经支配中看到的变化。然而,到死亡时,通常会有相当多的其他神经元参与其中。
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Neurochemical Correlates of Dementia

Studies of the neurochemical pathology of AD have indicated that early in the course of the disease, abnormalities of relatively few neurotransmitters are obvious. The most reliable and consistent changes are those seen in the cholinergic innervation of the cortex and the cortical pyramidal neurones. However, by the time of death there is usually considerable involvement of other neurones.

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