Stanley I. Rapoport, Kimmo Hatanpää, Daniel R. Brady, Krish Chandrasekaran
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Brain Energy Metabolism, Cognitive Function and Down-regulated Oxidative Phosphorylation in Alzheimer Disease
Reduced brain glucose utilization in early stages of Alzheimer disease, as measured within vivopositron emission tomography, reflects potentially reversible down-regulation of gene expression for oxidative phosphorylation within neuronal mitochondria. Such down-regulation may occur when neuronal energy demand is first reduced by synaptic dysfunction or loss.
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