神经生长锥的钙和趋化转向

Perspectives on developmental neurobiology Pub Date : 1996-01-01

J Q Zheng, M M Poo, J A Connor

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引用次数: 0

摘要

培养的章鱼脊髓神经元表现出趋化性转向神经递质乙酰胆碱和谷氨酸的来源。在此，我们回顾了实验证据，即递质诱导的生长锥转向是由 Ca2+ 的流入介导的，生长锥内的细胞内 Ca2+ 梯度是生长锥定向反应的原因，不对称丝状体的形成先于转向反应，并且对转向反应至关重要。

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Calcium and chemotropic turning of nerve growth cones.

Cultured Xenopus spinal neurons exhibit chemotropic turning toward the source of neurotransmitters acetylcholine and glutamate. Here we review the experimental evidence that transmitter-induced turning of the growth cone is mediated by an influx of Ca2+, that a gradient of intracellular Ca2+ within the growth cone is responsible for the directional growth cone response, and that asymmetric filopodia formation precedes and is essential for the turning response.

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Perspectives on developmental neurobiology

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