肺炎衣原体和动脉粥样硬化——最新进展。

P Saikku
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摘要

肺炎衣原体在动脉粥样硬化中的作用是目前研究该病发病机制的研究人员存在争议和忽视的问题。大量的血清流行病学研究表明,肺炎支原体感染与冠心病有关,最近的研究表明,肺炎支原体在动脉粥样硬化病变中普遍存在。到目前为止,大多数心脏病专家更倾向于认为,在动脉粥样硬化病变中发现的肺炎梭菌是良性颗粒,从循环沉积到预先形成的病变中,而不是作为参与或启动炎症过程的已知致病性革兰氏阴性细菌。后一种可能会导致脂蛋白氧化,并诱导细胞因子和蛋白水解酶的产生。这些现象是动脉粥样硬化的典型表现。衣原体可以用抗生素治疗,并且验证细菌感染的治疗重要性可能是显著的。
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Chlamydia pneumoniae and atherosclerosis--an update.

The role of Chlamydia pneumoniae in atherosclerosis is at present controversial and neglected by researchers studying the pathogenesis of the disease. Numerous seroepidemiological studies have shown an association of C. pneumoniae infection with coronary heart disease and recent studies have indicated the ubiquitous presence of C. pneumoniae in the atherosclerotic lesions. The majority of cardiologists are, as yet, more apt to consider the finding of C. pneumoniae in atherosclerotic lesions as benign particles deposited from the circulation into preformed lesions rather than as a known pathogenic Gram-negative bacterium participating in or initiating an inflammatory process. The latter possibility would result in the oxidation of lipoproteins and the induction of cytokines and proteolytic enzyme production. These phenomena are typical for atherosclerosis. Chlamydia are amenable for treatment with antibiotics, and the therapeutic importance of the verification of bacterial involvement could be significant.

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