感染和运动之间的相互作用,特别是心肌炎和1979- 1992年瑞典年轻定向运动员猝死频率的增加。

G Friman, E Larsson, C Rolf
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引用次数: 0

摘要

感染和发烧引起细胞因子介导的宿主反应,导致负氮平衡,肌肉蛋白降解,包括骨骼肌和心肌,以及肌肉功能恶化。体育锻炼有相反的效果。适度的体育锻炼也会刺激免疫系统,而彻底和持久的运动之后会出现暂时的免疫缺陷和呼吸道感染的易感性增加。在感染的急性期进行运动可能会引起并发症,包括心肌炎。心肌炎患者的运动与机体相关以及免疫介导的组织损伤增加有关。1979- 1992年间,瑞典年轻男性定向运动员猝死(SUD)率有所上升,这表明存在(a)共同的潜在原因。心肌炎是最明显的组织病理特征之一。据推测,肺炎衣原体或在诊断试验中产生交叉反应的类似生物是导致死亡率增加的一个因素。高频率的高强度运动是死者的常见做法,可能会抑制免疫,促进严重心肌疾病的发展。
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Interaction between infection and exercise with special reference to myocarditis and the increased frequency of sudden deaths among young Swedish orienteers 1979-92.

Infection and fever evoke a cytokine-mediated host response resulting in negative nitrogen balance, muscle protein degradation, which includes the skeletal muscles as well as the heart muscle, and deteriorated muscle function. Physical training has an opposite effect. Moderate physical training also stimulates the immune system, whereas exhaustive and longlasting exercise is followed by a temporary immunodeficiency and an increased susceptibility to respiratory tract infections. Exercise in the acute phase of an infection may promote complications including myocarditis. Exercise in myocarditis is associated with increased organism-associated as well as immune mediated tissue damage. An increased sudden death (SUD) rate among young Swedish male orienteers existed in 1979-92, suggesting (a) common underlying cause(s). Myocarditis was one of the most conspicuous histopathological features. Chlamydia pneumoniae, or a similar organism cross reacting in diagnostic tests, is hypothesized to be a factor causing this increased death rate. High frequency of intense exercise sessions, which was a common practice among the deceased, may have been immunosuppressive, promoting the development of severe myocardial disease.

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