{"title":"印度钦奈(泰米尔纳德邦)恶性疟原虫对氯喹的体内和体外敏感性。","authors":"V K Dua, P K Kar, N C Gupta, I Kar, V P Sharma","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>In-vitro and in-vivo susceptibility of Plasmodium falciparum to chloroquine were conducted at Chennai city, India. Eighteen (60%) out of 30 cases showed resistance in in-vitro study. EC50 of resistant and sensitive cases were 0.40 and 0.24 mumol chloroquine/l blood respectively, while EC90 were 2.64 and 0.84 mumol chloroquine/l blood respectively. In-vivo tests identified 24 cases (40%) as resistant (23 RI and 1 RII) and 36 (60%) as sensitive out of 60 cases. Eight isolates which were found resistant with in-vitro tests showed sensitive behaviour to chloroquine treatment assessed by in-vivo studies.</p>","PeriodicalId":77174,"journal":{"name":"Indian journal of malariology","volume":"34 1","pages":"1-7"},"PeriodicalIF":0.0000,"publicationDate":"1997-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In-vivo and in-vitro sensitivity of Plasmodium falciparum to chloroquine in Chennai (Tamil Nadu), India.\",\"authors\":\"V K Dua, P K Kar, N C Gupta, I Kar, V P Sharma\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In-vitro and in-vivo susceptibility of Plasmodium falciparum to chloroquine were conducted at Chennai city, India. Eighteen (60%) out of 30 cases showed resistance in in-vitro study. EC50 of resistant and sensitive cases were 0.40 and 0.24 mumol chloroquine/l blood respectively, while EC90 were 2.64 and 0.84 mumol chloroquine/l blood respectively. In-vivo tests identified 24 cases (40%) as resistant (23 RI and 1 RII) and 36 (60%) as sensitive out of 60 cases. Eight isolates which were found resistant with in-vitro tests showed sensitive behaviour to chloroquine treatment assessed by in-vivo studies.</p>\",\"PeriodicalId\":77174,\"journal\":{\"name\":\"Indian journal of malariology\",\"volume\":\"34 1\",\"pages\":\"1-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian journal of malariology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian journal of malariology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In-vivo and in-vitro sensitivity of Plasmodium falciparum to chloroquine in Chennai (Tamil Nadu), India.
In-vitro and in-vivo susceptibility of Plasmodium falciparum to chloroquine were conducted at Chennai city, India. Eighteen (60%) out of 30 cases showed resistance in in-vitro study. EC50 of resistant and sensitive cases were 0.40 and 0.24 mumol chloroquine/l blood respectively, while EC90 were 2.64 and 0.84 mumol chloroquine/l blood respectively. In-vivo tests identified 24 cases (40%) as resistant (23 RI and 1 RII) and 36 (60%) as sensitive out of 60 cases. Eight isolates which were found resistant with in-vitro tests showed sensitive behaviour to chloroquine treatment assessed by in-vivo studies.
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