固相法合成氮扎丙氨酸肽。

Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity Pub Date : 1996-01-01

C J Gray, N I Desai, R Gorst, G Masih

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摘要

将扎扎氨基酸残基掺入固相法合成的多肽的方法已经扩展到允许制备扎扎丙氨酸多肽。以这种方法制备了h - ala - ala - lys - glu - ala - glu - lys - ala - glu - lys - ala - azaala - glu - leu - n2h3和h - ala - azaala - lys - glu - ala - glu - lys - ala - glu - lys - ala - glu - lys - ala - glu - leu - la- glu - leu - la-Leu-N2H3。制备了一种新的Ala-Gly序列类似物3-氮杂阿兰酰丙酸，并用它制备了类似物乙酰- leu - ser - gly -azaala -3- prop - ph - ser - leu - nh2。

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Synthesis of azaalanine peptides using the solid phase method.

The methodology for the incorporation of azaamino-acid residues into peptides synthesised by a solid-phase method has been extended to allow azaalanine peptides to be prepared. In this way, Ac-Leu-Ser-Gly-azaAla-Gly-Phe-Ser-Leu-NH2 H-Ala-Ala-Lys-Glu-Ala-Ala-Glu-Ala -Ala-Glu-Lys-Ala-azaAla-Glu-Leu-Ala-Leu-N2H3, and H-Ala-azaAla-Lys-Glu-Ala-Ala-Glu-Ala-Ala-Glu-Lys-Ala-Ala-Glu-Leu-A la-Leu-N2H3 have been prepared. A new analogue of the Ala-Gly sequence, 3-azaalanylpropionic acid has been prepared and used to prepare the peptide analogue acetyl-Leu-Ser-Gly-azaAla-3-Prop-Phe-Ser-Leu-NH2.

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Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity

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