{"title":"含有新型抗hiv药物ADRT的双链DNA的稳定性和构象。","authors":"N J Gibson, C M McKellar, T Brown","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The anti-HIV drug 4'-azidothymidine (ADRT) has been incorporated into DNA by the phosphoramidite method. The presence of the modified nucleotide was shown to have a minimal effect on duplex conformation and stability by CD spectroscopy and UV melting.</p>","PeriodicalId":8980,"journal":{"name":"Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity","volume":"2 1","pages":"23-5"},"PeriodicalIF":0.0000,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The stability and conformation of duplex DNA containing the novel anti-HIV drug ADRT.\",\"authors\":\"N J Gibson, C M McKellar, T Brown\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The anti-HIV drug 4'-azidothymidine (ADRT) has been incorporated into DNA by the phosphoramidite method. The presence of the modified nucleotide was shown to have a minimal effect on duplex conformation and stability by CD spectroscopy and UV melting.</p>\",\"PeriodicalId\":8980,\"journal\":{\"name\":\"Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity\",\"volume\":\"2 1\",\"pages\":\"23-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The stability and conformation of duplex DNA containing the novel anti-HIV drug ADRT.
The anti-HIV drug 4'-azidothymidine (ADRT) has been incorporated into DNA by the phosphoramidite method. The presence of the modified nucleotide was shown to have a minimal effect on duplex conformation and stability by CD spectroscopy and UV melting.
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