合成抗原肽作为肿瘤免疫治疗的新策略。

E Appella, D J Loftus, K Sakaguchi, A Sette, E Celis
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引用次数: 0

摘要

主要组织相容性复合体(MHC)的I类呈递抗原被CD8+细胞溶解效应细胞(ctl)的T细胞受体识别,而II类分子向CD4+辅助T细胞呈递抗原。无论是I类分子还是II类分子,其结构和功能都是通过肽的结合联系在一起的。已经获得了与各种I类和II类分子结合的天然加工肽的共识或单个序列,揭示了与MHC分子相关的肽的一般特征。通过对几种不同MHC分子的三维结构的表征,肽与MHC分子之间的相互作用得到了更清晰的定义。ctl与针对肿瘤的免疫反应有关,现在有充分的证据表明,一些人类肿瘤表达特定的抗原,这些抗原被ctl识别,并可能用于免疫治疗方案。使用抗原肽在体内引起特异性和有效的CTL反应比使用其他抗原片段有几个优点。安全有效地给人施用多肽的新策略可能导致它们在癌症的免疫预防和治疗中使用。
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Synthetic antigenic peptides as a new strategy for immunotherapy of cancer.

Antigens presented by class I of the major histocompatibility complex (MHC) are recognised by the T cell receptor of CD8+ cytolytic effector cells (CTLs), while class II molecules present antigens to CD4+ helper T cells. For both class I and class II molecules, structure and function are linked through the binding of peptides. Consensus or individual sequences have been obtained for naturally processed peptides bound to a variety of class I and class II molecules, revealing the general features of peptides associated with MHC molecules. The interactions between peptides and MHC molecules have been more clearly defined by the characterization of the three dimensional structure of several different MHC molecules. CTLs have been implicated in immune responses against tumors and it is now well documented that some human tumors express specific antigens, which are recognised by CTLs and could potentially be used in immunotherapy protocols. The use of antigenic peptides to elicit a specific and effective CTL response in vivo offers several advantages over the use of other antigenic moieties. Emerging strategies for the safe and effective administration of peptides to humans may lead to their use in the immunological prevention and treatment of cancer.

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